Sat.Feb 15, 2025 - Fri.Feb 21, 2025

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A new, costly cancer drug vs placebo; Cabozantinib in neuroendocrine tumors; How NIH funded trials can fail patients and payers

Sensible Medicine

John is sick, so I have big shoes to fill. Today’s study of the week is a cancer trial. I know many of you aren’t cancer doctors, and you are thinking about skipping this essay. Let me assure you: you will learn something. The trial has issues with control arm, skewed randomization (2:1), drop out and endpoints. It is a rollercoaster ride of critical appraisal.

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Misinformation Doctors Start a Misinformation Journal to Spread Misinformation

Science Based Medicine

There is no doubt the "studies" in this journal will conclude We Want Them Infected doctors were right about everything the whole time; mitigation measure were an epic catastrophe while COVID was a harmless cold for everyone but grandma. The post Misinformation Doctors Start a Misinformation Journal to Spread Misinformation first appeared on Science-Based Medicine.

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Abstracts from international emergency medicine journals

Emergency Medicine Journal

Editor’s note: EMJ has partnered with the journals of multiple international emergency medicine societies to share from each a highlighted research study, as selected by their editors. This edition will feature an abstract from each publication.

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Annals ECG of The Month

ACEP Now

Emergency medical services (EMS) were called to the home of a 22-year-old woman after a syncopal episode and seizure-like activity. The patient reported consuming plant needles obtained online in a suicide attempt several hours prior. On EMS arrival, the patient was alert, pulse was fluctuating between 40 and 130 beats/min, and manual systolic blood pressure was 60 mmHg.

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Antibiotic Management of Nonperforated Appendicitis is Inferior to Appendectomy

Sensible Medicine

For decades, the treatment of acute appendicitis was appendectomy. Nobody even questioned this treatment approach. The appendix was acutely inflamed, at risk of perforation, it needed to be removed. The idea that there could be a simple, non-surgical management could not have been imagined. But, eventually evidence would accumulate casting doubt on this paradigm.

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“Don’t Worry About the NIH” From the Same Doctors Who Brought You “Don’t Worry About COVID.”

Science Based Medicine

Although many doctors who spread COVID misinformation act as if its in poor taste to bring it up today, we don't need their permission to remember. The post Dont Worry About the NIH From the Same Doctors Who Brought You Dont Worry About COVID. first appeared on Science-Based Medicine.

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Pediatric Collaborative Preview | How caregiver wellness shapes experiences

NRC Health

This years lineup includes many great presentations, including a session focused on reclaiming the practices of resilience by focusing on the power to find the I within resiliency. The post Pediatric Collaborative Preview | How caregiver wellness shapes experiences appeared first on NRC Health.

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Neuroimaging Cases 008

Life in the Fast Lane

Michael Gibbs MD Neuroimaging Cases 008 Intraventricular rupture of brain abscess (IVROBA). Second in our Neuroimaging case study series with Teresa Crow, Troy Carnwath, Scott DiMeo, L.

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It’s the end of the world as I know it. And I feel fine.

Science Based Medicine

Pondering the future of a few infections. As to the image, consider it a metaphor of before and after where Jesus is a stand in for science or public health or whatever you want him to be. Except a promoter of peace and helping the poor. Not in 2025 anyway. See [link] for more. The post Its the end of the world as I know it. And I feel fine. first appeared on Science-Based Medicine.

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Peds Collab Preview | How caregiver wellness shapes experiences

NRC Health

This years lineup includes many great presentations, including a session focused on reclaiming the practices of resilience by focusing on the power to find the I within resiliency. The post Peds Collab Preview | How caregiver wellness shapes experiences appeared first on NRC Health.

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Boosting blood pressure in critically ill patients is not always wise

The Evolution & Medicine Review

By Joe Alcock Many advances in the care of critically ill patients over time have involved intervening less aggressively. A recent perspective by DAmico and colleagues (1) builds on that tradition of less is more. In Protective Hemodynamics: C.L.E.A.R.! the authors urge caution in treating low blood pressure with fluids or vasopressor medications. DAmico, F.

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Fusariosis

Life in the Fast Lane

Chris Nickson Fusariosis CCC entry for fusariosis / Fusarium infections (infectious disease)

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PEERLESS: Interventional therapies for pulmonary embolism

First 10 EM

The decision between mechanical thrombectomy and catheter directed thrombolysis for pulmonary embolism is not one that most emergency physicians are making. Most (like me) probably dont even have access to such therapies, which might be a good thing, as both therapies remain completely unproven. However, I thought I would share the PEERLESS trial as a […] The post PEERLESS: Interventional therapies for pulmonary embolism appeared first on First10EM.

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Single-Dose vs. Multi-Dose Epinephrine

Emergency Medicine Education

A pre-post study conducted in North Carolina compared multi-dose epinephrine with single-dose epinephrine in adult non-traumatic out-of-hospital cardiac arrest (OHCA) patients. The authors concluded that patients with bystander CPR and a shockable rhythm who received only a single dose of epinephrine had a higher survival rate to hospital discharge compared to those who did not receive bystander CPR and had multiple doses of epinephrine.

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How long should CPR be performed after cardiac arrest in the hospital?

PulmCCM

Cardiopulmonary resuscitation (CPR) is performed on more than 250,000 people in U.S. hospitals each year. When a patient is failing to recover spontaneous circulation, the clinician in charge must decide whether and when to cease resuscitation efforts. Moments after he or she says “stop,” the person will be declared legally dead. It’s an awesome and humbling responsibility, the ultimate life-and-death decision.

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Comprehensive Management of the Hypoxic Patient for Healthcare Professionals Training

American Medical Compliance

Hypoxia can lead to severe complications if not addressed promptly and effectively. As healthcare professionals, understanding the complexities of managing hypoxia is crucial to providing high-quality care. This training course is designed to equip healthcare personnel with the knowledge and practical skills needed to recognize, assess, and manage hypoxic patients.

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ECG Blog #469 — Epigastric Pain with Dinner

Ken Grauer, MD

The ECG in Figure-1 was obtained from a middle-aged woman who presented to the ED ( E mergency D epartment ) for epigastric pain that had begun ~1 hour earlier. The epigastric pain began during dinner. She was diagnosed in the ED as having gastritis. The 1st Troponin was not elevated. QUESTIONS: How would you interpret the initial ECG in Figure-1? Does the negative initial Troponin rule out an acute event?

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McSwain’s Rules of Patient Care

The Trauma Pro

It’s been five years since I published my Laws of Trauma, and it’s time to dust them off again. In the meantime, I’ve added a couple of new ones. But before I start publishing them I’d like to take a moment to share “McSwain’s Rules of Patient Care.” I met Norm McSwain when I was junior faculty at the University of Pennsylvania.

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Active and Passive Academic Freedom

Sensible Medicine

In a NYTimes op-ed by former NCI and NIH director, and Nobel Laureate, Harold Varmus, Varmus argues that future NIH director Jay Bhattacharya is wrong to tie NIH funding to academic freedom. He calls the plan “outlandish” Varmus’ claim begs the questions: What is academic freedom? Is there a public interest to incentivize universities that honor it?

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Maternal and Neonatal Outcomes Following Resuscitative Hysterotomy for OHCA. Time and survival #dogmalysis.

St. Emlyn

St.Emlyn's - Emergency Medicine #FOAMed Background Resuscitative hysterotomy, also known as perimortem caesarean section, is a high-stakes, time-critical intervention performed in pregnant women who experience cardiac arrest. It’s also one of the most daunting HALO […] The post Maternal and Neonatal Outcomes Following Resuscitative Hysterotomy for OHCA.

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Apple Cider Vinegar

Science Based Medicine

I just watched the new Netflix series, Apple Cider Vinegar, which tells the story of Belle Gibson, an Australian woman who launched a wellness business based largely on the false claim that she had survived “terminal brain cancer” It is worth a watch, and overall I feel the writers (this is a fictionalized version, not a documentary) captured the industry of fake […] The post Apple Cider Vinegar first appeared on Science-Based Medicine.

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The First Law Of Trauma

The Trauma Pro

Let’s get started with the Laws of Trauma! After pursuing any discipline for an extended period, one begins to see the common threads and underlying principles of their area of expertise. Ive been trying to crystallize these for years, and today Im going to share one of the most basic laws of trauma care. The First Law of Trauma Any anomaly in your trauma patient is due to trauma, no matter how unlikely it may seem.

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Why most medical research is likely (still) waste, and less research funding may be one way forward

Sensible Medicine

As always, we are happy to feature articles that expand on ideas discussed on Sensible Medicine – even when the author agrees more with Dr. Prasad than with me. Today, we welcome back Dr. Raudasoja, who last published with us about a year ago. Adam Cifu Sensible Medicine is a reader-supported publication. If you appreciate our work, consider becoming a free or paid subscriber.

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Is Diastolic Blood Pressure the New Resuscitation Target

St. Emlyn

St.Emlyn's - Emergency Medicine #FOAMed This week I read a great article in the EMJ by Dan Horner and Rich Carden on new resuscitation targets. notably the use of diastolic blood pressure. DBP is the […] The post Is Diastolic Blood Pressure the New Resuscitation Target appeared first on St.Emlyn's.

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ECG Cases 54 The Art of Occlusion MI: Scale and Proportionality

Emergency Medicine Cases

On this month's ECG Cases, Dr. Jesse McLaren explains how STEMI criteria can be false positive with large scale QRS and proportional ST elevation, or false negative with low/normal scale QRS and disproportionate ST elevation and hyperacute T waves, and that rules for subtle occlusion using proportionality can help differentiate LBBB with or without Occlusion MI, or LV aneurysm vs anterior STEMI with Q waves.

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What factor determines final diagnosis of STEMI vs. NSTEMI? Is it ST Elevation? Occlusion? or Something else? What?

Dr. Smith's ECG Blog

The answer is at the bottom, and illustrated by this case. Written by Willy Frick A man in his mid 30s with type 1 diabetes presented with two days of midsternal and epigastric pain, described as both "sharp" and squeezing." There was associated nausea, vomiting, and dyspnea. He said the pain was worse with supination and improved with upright posture.

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Whining Doctors and the Patients They Whine About

Sensible Medicine

Of all the inane compliance videos, courses, and quizzes I have been forced to tolerate during my career, the only memorable one was this video , made by (for?) the Cleveland Clinic. If you haven’t watched it, it is actually worth five minutes of your time. It reminds me that I never truly know what other people are living with and that I am privileged to do what I do.

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Podcast – Moral Injury with Caroline Leech at Tactical Trauma 24

St. Emlyn

St.Emlyn's - Emergency Medicine #FOAMed The St Emlyns podcast delves into moral injury in healthcare with Dr. Caroline Leech. Learn how repeated exposure to ethical dilemmas leads to distress and explore strategies to mitigate its impact on clinicians. The post Podcast – Moral Injury with Caroline Leech at Tactical Trauma 24 appeared first on St.Emlyn's.

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AMC President Mark Gutweiler Expands into UAE & Middle East at Arab Health 2025

American Medical Compliance

AMC (American Medical Compliance) has achieved a major milestone by expanding into the UAE, Saudi Arabia, and the broader Middle East, reinforcing its position as a key player in global healthcare compliance. At the forefront of this initiative, AMC President Mark Gutweiler led the companys participation in Arab Health 2025 , one of the worlds most prestigious healthcare exhibitions , held in Dubai.

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After seeing this ECG, are there any medications you would consider giving?

Dr. Smith's ECG Blog

Written by Willy Frick A man in his 50s with COPD presented with dizziness and hypotension. He had worked overnight the night before and presented to the hospital after his shift. His first recorded blood pressure was 88/53 mm Hg. Here is his presenting ECG: What do you think? The ECG shows sinus rhythm. The T waves are suspiciously symmetric, but not hyperacute looking.

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What I Read Last Week

Sensible Medicine

One of the ways I am dealing with empty nest syndrome is by accepting invitations to visit other medical centers. These visits have been absolute pleasures. Giving talks is enjoyable and a bit of an ego boost. Getting to visit the local museums and see old friends who live in the area is a treat. The real highlight, though, is sitting and talking in person to colleagues who have previously only been virtual.

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Response to: correspondence on 'subarachnoid haemorrhage in the emergency department (SHED): a prospective, observational, multicentre cohort study by Deng and Chen

Emergency Medicine Journal

We thank the authors for their commentary 1 on the Subarachnoid Haemorrhage in the Emergency Department (SHED) study. 2 We agree that the lack of ethnicity reported in the SHED study is a limitation affecting the generalisability of our findings, as highlighted in the discussion. This study was first designed in 2018 for primary implementation by the Trainee Emergency Research Network (TERN), a group of resident emergency medicine clinicians with variable access to research nurse support or acad

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Social Determinants of Health Training

American Medical Compliance

The Social Determinants of Health (SDOH) Training is designed to equip healthcare providers with essential knowledge about the factors beyond medical care that impact patient health. Understanding SDOH is critical, as social and environmental conditions, such as economic stability, education, healthcare access, and community support, play a significant role in health outcomes.

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Rural EM and Traumatic ICH – An Interview with Ashley Weisman, MD

EB Medicine

In this episode, Sam Ashoo, MD interviews Ashley Weisman, MD about her career in rural emergency medicine, and the February 2025 Emergency Medicine Practice article, Management of Traumatic Intracranial Hemorrhage in the Emergency Department Interview with Dr. Ashley Wiseman Introduction of Dr. Wiseman: Emergency physician specializing in rural ER. Dr.

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Webcast Recap: Key updates on 2025 HCAHPS and patient experience strategies

NRC Health

Discover the latest updates from NRC Health's CAHPS Insider Live webcast, including new HCAHPS 2025 survey dimensions, care coordination, hospital environment restfulness, and symptom information. Learn best practices for data goal-setting and increasing CAHPS participation. The post Webcast Recap: Key updates on 2025 HCAHPS and patient experience strategies appeared first on NRC Health.

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Letter to the editor regarding 'subarachnoid haemorrhage in the emergency department (SHED): a prospective, observational, multicentre cohort study

Emergency Medicine Journal

We wish to commend the authors of the recent study, ‘Subarachnoid haemorrhage in the emergency department (SHED): a prospective, observational, multicentre cohort study’, for their insightful contributions to the understanding of subarachnoid haemorrhage (SAH) diagnostics. 1 However, we believe that certain aspects merit further discussion, particularly regarding the implications of their findings for clinical practice and equity in healthcare.

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Monitoring Vital Signs for Healthcare Professionals

American Medical Compliance

Monitoring vital signs is a fundamental aspect of patient care, providing critical insights into a patient’s health status. Accurate measurement and interpretation of vital signs can help detect early signs of deterioration, enabling timely interventions. This course will cover essential techniques for measuring vital signs, interpreting readings, recognizing early warning signs of patient decline, and ensuring proper documentation.

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