Sensible Medicine

JANUARY 23, 2025

His research has led him to a pretty clear opinion about the role of seed oils in health and disease. However, a meta-analysis of 30 observational studies across 13 countries found that higher levels of linoleic acid in the blood were associated with a lower risk of heart disease and stroke.

Wellness 111

Wellness Stroke Research 111

ACEP Now

SEPTEMBER 6, 2024

This comes out of INTERACT-4, a trial testing the efficacy of blood pressure reduction in undifferentiated acute stroke syndromes. Without delving into too much detail, approximately half of the over 2,300 patients in the trial suffered ischemic stroke, and the remainder hemorrhagic stroke.

Research 49

Research Stroke Outcomes Sepsis 49

RebelEM

SEPTEMBER 7, 2023

BACKGROUND: intracerebral hemorrhage (ICH) makes up 10-15% of all strokes and significantly contributes to overall stroke-related morbidity and mortality ( Hostettler 2019 ). About 30% of patients experience early seizures within seven days following the onset of a stroke ( Peter-Derex 2022 ).

Seizures 132

Seizures Stroke Outcomes Research 132

The Skeptics' Guide to EM

AUGUST 20, 2022

Fragility Index Meta-Analysis of Randomized Controlled Trials Shows Highly Robust Evidential Strength for Benefit of The post SGEM Xtra: Are tPA Stroke Trials Really Fragile? I knew about Jeff from his multiple publications in the stroke literature. first appeared on The Skeptics Guide to Emergency Medicine. This is an SGEM Xtra.

Stroke 52

Stroke Best Practices EMS Research 52

ACEP Now

MARCH 6, 2024

Every year, the volume of published research continues to outpace capacity to consume. What’s New in Stroke Care? The simplicity of tenecteplase administration makes its use likely the preferred agent for treating acute ischemic stroke. the “ARAMIS” trial throws up another red flag for patients suffering mild stroke.

Research 52

Research Airway Management Stroke Outcomes 52

Stop and Think

DECEMBER 29, 2023

For an older patient with stroke risk factors and 3 hours of AF on a cardiac device, pre-2023 thinking would have us leaning toward anticoagulation. Edoxaban reduced the primary endpoint of stroke, systemic embolism, and cardiovascular death by 19% (HR, 0.81; 95% CI, 0.60-1.08; hours) to edoxaban vs placebo. I don’t know.

Stroke 92

Stroke EKG/ECG Research Wellness 92

Emergency Live

AUGUST 2, 2024

A large-scale study, conducted in the United Kingdom and published in the prestigious journal Nature Communications, revealed a surprising link between vaccination and a […] The post Decrease in heart attacks and strokes after anti-Covid vaccination appeared first on Emergency Live.

Stroke 52

Stroke Research 52

EMDocs

JANUARY 29, 2024

This article will discuss blood pressure goals and preferred pharmacotherapy for non-traumatic ischemic and hemorrhagic strokes. Ischemic Strokes: Ischemic stroke is characterized by a blockage of a blood vessel in the brain. The BP targets for patients with ischemic strokes depend on the available therapeutic options.

Stroke 101

Stroke Outcomes EMS Seizures 101

The Skeptics' Guide to EM

FEBRUARY 26, 2019

This has been through various peer reviewed publications, doing Emergency Medicine Abstracts (EMA) audio program […] The post SGEM Xtra: No Retreat, No Surrender – Thrombolysis for Acute Ischemic Stroke first appeared on The Skeptics Guide to Emergency Medicine. It appears his concerns may have come true. Six trials showed no benefit.

Stroke 52

Stroke EMS Research Outcomes 52

Sensible Medicine

AUGUST 26, 2024

Strokes and heart failure are the main complications of AF. And even when drugs suppress AF, trials failed to show that doing so reduces stroke or heart failure. The SHAM-PVI trial Next weekend at the European Society of Cardiology meeting in London, a UK team of researchers will present results of the SHAM-PVI trial.

Stroke 100

Stroke Outcomes Shock Research 100

Taming the SRU

AUGUST 7, 2023

The patient needs a transvaginal ultrasound w/ doppler with gynecology consult and possible laparotomy TVUS is not just for torsion, it can also be used for ectopic pregnancies or pregnancy of unknown location Acute Ischemic Stroke Updates WITH Drs. Research Grand rounds WITH Drs. The expanded window of 3-4.5

Stroke 93

Stroke Outcomes EKG/ECG Research 93

Sensible Medicine

NOVEMBER 28, 2023

i] Though I’ve never been a traditional researcher, I’ve added quite a bit to “medical literature” over the years. The primary outcome was stroke or systemic embolism and the primary safety outcome was major bleeding. years, anticoagulation reduced the rate of stroke or systemic embolism by 1.7% (HR: 0.63; 0.45

Stroke 97

Stroke Academics Outcomes Administration 97

Sensible Medicine

JULY 15, 2024

I would propose that it is 90% due to misplaced incentives and 10% misunderstanding about epidemiologic research. No patient checks in to their clinic or the ER to announce that they have not had a stroke because of the drug. Readers of Sensible Medicine know about the incentive problem. Because neurosurgeons see brain bleeds.

Stroke 124

Stroke Research Outcomes 124

Taming the SRU

JULY 25, 2024

Femoral nerve block case review - morbidity & mortality - community practice - r2 Clinical pathologic case - visual diagnosis - when time matters - operational aspects of stroke care Femoral nerve Block Case Review WITH dr. stolz Why do we care about regional anesthesia, specifically femoral nerve blocks? Staphylococcus spp.,

Stroke 98

Stroke Fractures Operations Outcomes 98

Medagadget

OCTOBER 19, 2023

Researchers at the University of Cincinnati have developed a lateral flow assay that can detect bacterial toxins from Porphyromonas gingivalis , the causative bacteria for gingivitis. In this instance, these researchers at the University of Cincinnati have developed a lateral flow assay to detect the bacteria responsible for gingivitis.

Point-of-Care Testing 85

Point-of-Care Testing Research Stroke Wellness 85

ACEP Now

OCTOBER 9, 2023

The concept of rapid assessment for heart attacks and strokes is not foreign to the general public, but these emergencies do not include rapid destruction of clothing, private examinations performed in front of audiences, or a quick succession of invasive procedures. with a professional focus on the care of critically ill patients.

Resuscitation 126

Resuscitation Research Stroke Emergency Department 126

Taming the SRU

OCTOBER 5, 2023

morbidity and mortality - quality improvement - research grand rounds - r1 clinical knowledge: pres/rcvs - r4 case follow-up: compartment syndrome Morbidity and Mortality WITH dr. finney Takotsubo Cardiomyopathy with COVID-19 Increasing incidence of Takotsubo Cardiomyopathy with the COVID-19 pandemic Morbidity and mortality is similar to that of ACS (..)

Stroke 91

Stroke EKG/ECG Seizures CPR 91

The Skeptics' Guide to EM

OCTOBER 3, 2020

She is the creator of the HEART Score and an enthusiastic researcher. Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA. NEJM […] The post SGEM#303: Two Can Make It – Less likely to have another stroke but more likely to have a bleed (THALES Trial) first appeared on The Skeptics Guide to Emergency Medicine.

Stroke 40

Stroke Emergency Department Research Wellness 40

RebelEM

SEPTEMBER 14, 2023

bleeding, stroke, limb ischemia, and hemolysis). Many centers have attempted ECLS to achieve hemodynamic stabilization in this group of patients. The benefits of this strategy may be outweighed by the risk of the device-related complications (i.e. The evidence for this practice has been sparse until now. Zeymer HT et al. Control: 53.4%

Shock 136

Shock Outcomes Resuscitation Stroke 136

RebelEM

FEBRUARY 29, 2024

3, 6 Among patients with stroke or traumatic brain injury (TBI), the risk may be as high as 28%-76% and 23%-60%, respectively. The authors rightfully note future research targets should include how/if the routine use of ceftriaxone increases antibiotic resistance in a population that is already quite vulnerable to devastating infection.

CDC 122

CDC Radiology Radiology Head Injuries 122

ACEP Now

MARCH 11, 2025

Dr. Westafer (@Lwestafer) is an attending physician and research fellow at Baystate Medical Center, clinical instructor at the University of Massachusetts Medical School in Worcester, and co-host of FOAMcast. Stubblefield WB, Helderman R, Strokes N, et al. References Khor YH, Smith R, McDonald CF. J Am Coll Cardiol. 2016;67(2):162-170.

Hospitals 52

Hospitals Administration Outcomes Stroke 52

Sensible Medicine

APRIL 29, 2024

Specification curve analysis is similar to a multiverse analysis, meaning it’s a way of defining and implementing all plausible and valid analytic approaches to a research question. Say blueberries and rates of stroke. This time in nutritional epidemiology. In other words: one way.

Stroke 142

Stroke Documentation/Coding Shock Research 142

American Medical Compliance

JUNE 28, 2024

For some, changes in the brain can affect mood and result in depression. Others may experience depression after a major life event, such as a medical diagnosis or the death of a loved one.

Stroke 98

Stroke Research Outcomes Wellness 98

Sensible Medicine

DECEMBER 4, 2023

When I started cardiology, much research focused on improving the care of people who had myocardial infarction (MI). A lot less research goes into post-MI care. Swedish and UK researchers had the idea that the drug dapagliflozin might improve outcomes in patients who have an MI big enough to cause mild heart damage.

Outcomes 103

Outcomes Research Hospitals Stroke 103

Taming the SRU

JULY 24, 2024

Population Patients were adult (18 or older) patients at a single academic emergency department who were triaged to a resuscitation bay and were not classified as a trauma, STEMI, stroke, cardiac arrest, or active labor. The physician was asked to do this at time point 15 minutes from patient arrival and 60 minutes from patient arrival.

Sepsis 89

Sepsis Resuscitation Emergency Department Wellness 89

Sensible Medicine

NOVEMBER 13, 2023

We call the primary endpoint of SELECT—CV death, MI or stroke—a hard cardiovascular endpoint. This newsletter often criticizes industry and biased researches. Meaning this was a secondary prevention study.) Patients in the trial were in their low sixties. The average BMI was 33 and patients weighed about 96 kilograms.

Outcomes 116

Outcomes Stroke Wellness Research 116

Sensible Medicine

MARCH 18, 2024

For example, our systematic review and meta-analysis of 21 RCTs found no consistent relationship between lowering LDL-Cholesterol with statins and the risk of death, heart attack or stroke. Sensible Medicine remains a place where non-establishment opinions can be published.

Stroke 145

Stroke Research 145

Stop and Think

OCTOBER 30, 2023

Outcomes included cardiac death, MI, emergency coronary revascularization or stroke. In making a judgment about the validity of this research, the editors were faced with the task of walking a fine line between skepticism and plausibility. The trial enrolled more than 3700 patients and the absolute risk reduction was 1.8%.

Stroke 123

Stroke Outcomes Research 123

EMDocs

NOVEMBER 20, 2023

High certainty of evidence: further research is unlikely to change the confidence in the estimate of the effect. Moderate certainty of evidence: further research is likely to have an important impact and may change the estimate. Low certainty of evidence: further research is very likely to change the estimate.

Resuscitation 104

Resuscitation Fluid Resuscitation Hospitals Research 104

Pediatric EM Morsels

JULY 21, 2023

Borgialli DA, Mahajan P, Hoyle JD Jr, Powell EC, Nadel FM, Tunik MG, Foerster A, Dong L, Miskin M, Dayan PS, Holmes JF, Kuppermann N; Pediatric Emergency Care Applied Research Network (PECARN). PMID: 1933914. Performance of the Pediatric Glasgow Coma Scale Score in the Evaluation of Children With Blunt Head Trauma. Acad Emerg Med. 107.498345.

Head Injuries 246

Head Injuries Pediatrics Outcomes Shock 246

Taming the SRU

APRIL 17, 2024

Results They studied 1852 patients in the MICU with the most common admission diagnoses being respiratory failure (34 %), sepsis (23 %), and primary CNS disease such as stroke or hemorrhage (23 %). Continuous data were analyzed using a student T-test and Wilcoxon rank-sum test and categorical data were analyzed via X2 test.

Sepsis 94

Sepsis Research Stroke Academics 94

Sensible Medicine

MARCH 11, 2024

This is where we get into all the terms you see in research papers: p-values, and confidence intervals (typically 95%) – and in the media - margin of error. Inferential statistics actually do NOT help us test a research hypothesis about whether an intervention worked or not. This is the null hypothesis (no effect).

Outcomes 118

Outcomes Research Stroke COPD 118

Taming the SRU

NOVEMBER 3, 2023

Broad strokes In this prospective, non-randomized study published by Kring et al in January 2022 out of Maine Medical Center, researchers compared mean pain scores at rest and during incentive spirometry before, at 15 minutes after, and then 60 minutes after treatment with a serratus anterior plane block. Ultrasound Med.

Fractures 98

Fractures Ultrasounds Research Outcomes 98

The Skeptics' Guide to EM

APRIL 8, 2023

John Brown PhD is a Professor of Health Services Research in Ireland who has been studying rural healthcare issues since 2012. The pre-specified subgroup analyses showed a decrease in in-hospital or 30-day mortality for myocardial infarction, stroke, aortic aneurysm, and major trauma but not for pneumonia, bowel perforation or hip fractures.

Stroke 57

Stroke Emergency Department COPD Academics 57

PulmCCM

JANUARY 6, 2025

Saudi Arabia is considered an authoritarian society, and internationally significant research projects have important political value to the monarchy. there is no validated method to diagnose sepsis; i.e., that unlike in diabetes, strokes, and bypass surgery, there is no way to reliably quantify the denominator in the SEP-1 quality metric).

Sepsis 45

Sepsis Documentation/Coding Hospitals Outcomes 45

PulmCCM

DECEMBER 12, 2024

However, embolized patients had nominally higher rates of death at 90 days (5% vs ~3%), functional deterioration (~12% vs ~10%), and disabling stroke (2 patients), leading authors to suggest caution while awaiting further safety data on the procedure.

Stroke 52

Stroke Operations Research 52

Sensible Medicine

APRIL 16, 2024

The only problem is that all these people were smokers, and they were not being followed for major adverse cardiovascular events (cardiovascular death, nonfatal MI, nonfatal stroke, or hospitalization for unstable angina -- MACE) which is what we use ASCVD to predict.

Radiology 96

Radiology Radiology Stroke Hospitals 96