Don't Forget the Bubbles

MAY 31, 2023

The DIMPLES study by PERUKI sought to investigate the incidence of new-onset diabetes in the paediatric population across the UK and Ireland, as well as the characteristics of these ED presentations, and to determine if SARS-CoV2 infection was involved. The patients were identified through site leads from the PERUKI research network.

Emergency Department 135

Emergency Department Research Documentation/Coding Outcomes 135

ACEP Now

SEPTEMBER 6, 2024

You may have mastered all the latest changes affecting management of sepsis, STEMI, and opiate-use disorder, but there’s no stopping the relentless revisions to our approach to neurologic emergencies. A greater number of patients randomized to “standard of care” attained modified Rankin scores of 0 to 3 than the Andexxa cohort, as well.

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Research Stroke Outcomes Sepsis 49

Sensible Medicine

JULY 29, 2024

Yet the failure of the hospital readmission penalty policy and sepsis protocols expose the risks of implementing a policy because it sounds good. Dr. Sarah Miller, an economist in the University Michigan business school, led the second trial, named the Open Research Unconditional Income Study or ORUS study.

Outcomes 106

Outcomes Research Sepsis Emergency Department 106

Taming the SRU

MARCH 30, 2023

10.1186/s13613-020-00658-8 P: A total of 761 patients from two separate cohorts found to have septic shock I: Diastolic shock index C: Comparison to a variety of well adopted markers of morbidity and mortality, including systolic shock index, SOFA score, APACHE II score, lactate, etc. Ann Intensive Care 2020;10(1):41.

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Shock Outcomes Sepsis Resuscitation 52

EB Medicine

OCTOBER 1, 2018

This month, we’ll be talking Updates and Controversies in the Early Management of Sepsis and Septic Shock. We have a special episode for you this month… We’ve brought Dr. Jeremy Rose, one of the peer reviewers, and a sepsis expert, on with us to talk through the content this month. Jeff : Sepsis chair. Sepsis-3!!

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Sepsis Shock Fluid Resuscitation Hospitals 40

The Skeptics' Guide to EM

NOVEMBER 18, 2017

Fever in the Emergency Department Predicts Survival of Patients With Severe Sepsis and Septic Shock Admitted to the ICU. Fever in the Emergency Department Predicts Survival of Patients With Severe Sepsis and Septic Shock Admitted to the ICU. Following the triage sepsis pathway, recently amended to use qSOFA. Probably not.

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Sepsis Emergency Department Seizures Pediatrics 52

The Skeptics' Guide to EM

SEPTEMBER 28, 2019

Dr. Carly Eastin is an Associate Professor, Division of Research and Evidence Based Medicine, Department of Emergency Medicine, University of Arkansas for Medical Sciences. But you remember seeing in the news there was a study claiming vitamin C could cure sepsis. This was because of a well-known critical care physician Dr. Paul Marik.

Sepsis 52

Sepsis Shock Outcomes Stroke 52

PulmCCM

OCTOBER 30, 2023

Professional Medical Societies Call for Elimination of SEP-1 The Infectious Diseases Society of America (IDSA), along with societies for emergency medicine physicians and hospitalists, are again speaking up about the ongoing policy experiment known as the Centers for Medicare and Medicaid Severe Sepsis/Septic Shock Management Bundle (SEP-1).

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Sepsis Shock Hospitals Infectious Diseases 52

Don't Forget the Bubbles

JULY 22, 2024

They were then able to run their planned subgroup analysis and see which variables were important to the research question. It’s undebatable that the authors have applied rigorous methodology to address this important research question. Each study was weighted proportionate to its contribution to the analysis.

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Outcomes Research Pediatrics Hospitals 105

Don't Forget the Bubbles

JANUARY 1, 2024

We suggest this list can help you discover relevant or interesting articles for your local journal club or allow you to keep a finger on the pulse of paediatric research. While adenotonsillectomy may not directly impact cognitive functions, it can benefit other aspects of health and well-being in children with mild sleep-disordered breathing.

Pediatrics 98

Pediatrics Ultrasounds Blood Transfusions Sepsis 98

Don't Forget the Bubbles

NOVEMBER 18, 2024

Various studies, such as those pooling data from the National Neonatal Research Database, indicate that the incidence of hypotension varies based on neonatal age, with the highest rates observed immediately post-birth and within the first days of life. Hypotension in the setting of sepsis may be one of the first signs of a systemic infection.

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Sepsis Shock Hyperthermia / Hypothermia Administration 59

Sensible Medicine

AUGUST 14, 2024

In popular (lay) understanding, SIDS represents a common danger that a well-cared for and apparently healthy baby will suddenly and terrifyingly be found dead in the morning. Researchers comb through the victims’ genomes for mutations in cardiorespiratory function and autonomic arousal systems. Dr. Paul N.

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CDC Sepsis Research Pediatrics 66

Don't Forget the Bubbles

JANUARY 10, 2024

The factorial design chosen by Dr Maitland and her research group means that several comparisons in transfusion practice could be carried out at the same time. What were the research questions? Does the study address a clearly focused research question? Groups were well matched at baseline. N Engl J Med.

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Blood Transfusions Outcomes Research Hospitals 78

The Skeptics' Guide to EM

DECEMBER 11, 2021

Date: December 10th, 2021 Guest Skeptic: Dr. Carly Eastin is an Associate Professor, Division of Research and Evidence Based Medicine, Department of Emergency Medicine, University of Arkansas for Medical Sciences. Back in 2019 we were talking about Vitamin C for sepsis ( SGEM#268 ). Not much has changed over the last two years.

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Sepsis Shock Outcomes Research 40

Northwestern EM Blog

JANUARY 24, 2022

Due to its extremely high morbidity and mortality as well as high healthcare costs, the prompt recognition, diagnosis and resuscitation of shock is key. Acidosis Acidosis in shock states can present from multiple different sources, including sepsis, hypoxemia, ingestions, hyperlactatemia from hypoperfusion, amongst others. 3) Farkas J.

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Anaphylaxis Shock Sepsis Resuscitation 52

EMDocs

JULY 26, 2023

2 In 1996, the World Health Organization (WHO) called for the remaining stocks of variola virus to be destroyed or transferred to one of two designated biosafety level 4 facilities: the Center for Disease Control (CDC) in Atlanta, Georgia or the State Research Center of Virology and Biotechnology in Koltsovo, Russia. McGraw-Hill; 2019.

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CDC Research Pediatrics Wellness 69

Thinking Critical Care

NOVEMBER 28, 2021

So after much deliberation, we have decided and are excited to bring the fourth edition of H&R back for 2022 – we had skipped 2021 to focus on some research papers and developing some courses (Flipping the Vent and The VExUS Course), but mostly because the virtual conferencing experience simply did not measure up to the live event.

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Sepsis Airway Management Wellness Resuscitation 52

Don't Forget the Bubbles

JULY 17, 2023

We suggest this list can help you discover relevant or interesting articles for your local journal club or allow you to keep a finger on the pulse of paediatric research. Evaluating the Impact of the 2017 Dutch Neonatal Early-Onset Sepsis Guideline. Paediatr Child Health. 2023 May 16;28(3):184-202. Van Rossem EJD, et al. 2023 Jun 15.

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Pediatrics Emergency Department Outcomes Fractures 98

Pediatric Emergency Playbook

APRIL 1, 2016

Brain natriuretic peptide (BNP) In adults, we typically think of a BNP Luckily, we have data in children with congenital heart disease as well. Lactate A sick child with sepsis syndrome? In the adult literature, we know that a lactate level above 4 mmol/L in patients with severe sepsis was associated with the need for critical care.

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Pediatrics Sepsis Shock Outcomes 52

Don't Forget the Bubbles

NOVEMBER 15, 2023

Jasmine, a hypothetical case Jasmine is a 5-year-old girl weighing 18kg admitted to PICU with suspected sepsis. As well as considering volume, hyponatraemia is a harmful consequence of incorrect administration of fluids. Remember, we can add more if needed, but taking it away is much harder. PMID: 29589054; PMCID: PMC5924672.

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EMDocs

JULY 1, 2023

Upon further research in the 1970’s, retrospective data from autopsies of those patients showed coronary aneurysms 5 Pathophysiology: Kawasaki Disease is a vasculitis of medium sized arteries.

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EMS Infectious Diseases Pediatrics Research 66

Mind The Bleep

JULY 23, 2023

Management: If well, babies with Hirschsprung’s can be managed in the first weeks-months of life with regular rectal washouts and later in life will have a pull through (Duhamel) procedure Contrast enema of a neonate with Hirschsprung’s disease. Sepsis causes an ileus or functional bowel obstruction. Parikh NS, I.

Sepsis 52

Sepsis Blood Transfusions Dehydration Wellness 52

The Skeptics' Guide to EM

FEBRUARY 10, 2018

Exclusions: Oxygen saturations <92% on room air; silent chest; shock or sepsis; previous PICU admission with wheeze; prematurity; other cardiac or respiratory disease; likely alternative diagnosis for the wheeze; or steroid treatment within the preceding 14 days. Intervention: Three-day course of oral prednisolone (1mg/kg once daily).

Emergency Department 40

Emergency Department Pediatrics Sepsis Hospitals 40

PulmCCM

JANUARY 4, 2022

As well, the volume of administration might be much lower than 500 mL, with previous research indicating that 4 mL/kg of crystalloid was an optimal volume needed to increase mean systemic filling pressure. Indeed, a recent consensus statement suggested a fluid challenge be 500 mL infused in less than 30 minutes.

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Wellness Outcomes Sepsis Stroke 40

PEMBlog

MARCH 27, 2024

She aims to become a physician-scientist in pediatrics and medical genetics, engaging in bench-to-bedside research that utilizes multi-omics-based approaches to provide a molecular diagnosis and support personalized care for individuals with suspected rare genetic diseases and their families. Or, well, the ringer called me.

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Pediatrics Seizures Emergency Department Sepsis 59

Don't Forget the Bubbles

NOVEMBER 6, 2024

We suggest this list can help you discover relevant or interesting articles for your local journal club or allow you to keep a finger on the pulse of paediatric research. Digital Detox and Well-Being. Update to the Neonatal Early-Onset Sepsis Calculator Utilizing a Contemporary Cohort. Catassi G, et al. Eur J Pediatr.

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Pediatrics Sepsis Fractures Hospitals 52

PulmCCM

FEBRUARY 19, 2024

Well … no. In my anecdotal experience, these phrases have an impressively high positive predictive value for badness (early sepsis, often). Maybe at Shands, although patients and families almost never actually called, care teams became more attentive, knowing they might? Patient-Centered, or Pandora’s Box?

Hospitals 52

Hospitals Resuscitation Burns Documentation/Coding 52

Taming the SRU

JULY 21, 2023

In infants, this can represent a medical emergency as it can quickly lead to orbital cellulitis and sepsis. Patients will often have objective visual acuity impairment as well as a fever or leukocytosis. Corneal ulcers are most frequently caused by Pseudomonas (especially if they wear contact lens), as well as S.

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Emergency Department EMS Burns Wellness 86

Don't Forget the Bubbles

OCTOBER 2, 2024

We suggest this list can help you discover relevant or interesting articles for your local journal club or allow you to keep a finger on the pulse of paediatric research. This referral procedure is only possible with a well-structured system and may not be feasible in all settings. Wyrwa JM, et al. Pediatrics. Deng J, et al.

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Pediatrics Hyperthermia / Hypothermia Emergency Department Urgent Care 52

Don't Forget the Bubbles

JUNE 10, 2024

Baby A, a preterm infant, appears to be faring well for the moment—requiring minimal respiratory support, on full feeds, without IV access, and generally in an okay condition. Systemic Infections : Sepsis and other systemic infections can predispose infants to NEC by compromising the gut barrier and promoting inflammation. Hunter, C.J.,

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Pediatrics Sepsis Fluid Resuscitation Outcomes 40

Taming the SRU

MAY 1, 2023

EMS was bagging him on arrival Primary notable for Compromised Airway Protection, bilateral Breath sounds, strong pulses,GCS 3 CT images of Head, Chest, Abdomen, Pelvis, and Spine No acute findings pH of 6.75

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Poisoning Hyperthermia / Hypothermia Seizures Emergency Department 52

EM Updates

JUNE 15, 2021

All patients admitted to the EDAT were identified on a daily report and their clinical course abstracted from the EHR onto a structured database by 2 research fellows and 7 emergency medicine residents. Other agents, also part of research protocols, were not similarly limited to intubated patients.

Emergency Department 52

Emergency Department Hospitals Outcomes Wellness 52

EMDocs

DECEMBER 18, 2023

Introduction Sepsis and septic shock are life-threatening conditions characterized by severe systemic inflammation and organ dysfunction due to a dysregulated host response to infection. 3,4 Prompt recognition and management of sepsis and septic shock are paramount for the ED clinician. vs. 0.91), positive predictive value (0.27

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Sepsis Fluid Resuscitation Resuscitation Shock 65

Mind The Bleep

FEBRUARY 27, 2024

1] It is worth mentioning this formula was designed for well, euvolaemic children, which does not represent the popluation of children who require IV fluids. saline), however more research is needed in this area. [4] Our population and their demographics has also changed significantly since this study in 1957.

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Fluid Resuscitation Hospitals Dehydration Research 96

RebelEM

MAY 15, 2024

The loss of these cells leads to immunosuppression as well as decreased responsiveness of the immune system as a whole Patients with neutropenia will not only get very sick very quickly, but also will have blunted immune response and may not localize signs of infection well Fever or malaise may be their only presenting symptoms.

Infectious Diseases 93

Infectious Diseases Administration Sepsis Anaphylaxis 93

PulmCCM

OCTOBER 23, 2023

Answering this research question has been made more difficult by pip-tazo’s possible status as a pseudo-nephrotoxin (elevating creatinine levels in the blood without harming the kidneys) and frequent co-administration with vancomycin, a known nephrotoxin.

Hospitals 98

Hospitals COPD Emergency Department CDC 98

Don't Forget the Bubbles

AUGUST 21, 2023

The baby’s parents tell you that the baby hasn’t been feeding well for a few days and today has been very sleepy. Infection/sepsis? About PICSTAR PICSTAR is a trainee-led research network open to all doctors, nurses and allied health trainees within Paediatric Intensive Care. What are your differentials? A metabolic issue?

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Pediatrics Outcomes Research Sepsis 98