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ToxCard: Second Generation Antipsychotic Overdose

EMDocs

1 Seizures may occur due to lowered seizure threshold. 6 Seizures have been observed and are dose-dependent. 1 Benzodiazepines are preferred as the first line of treatment for agitation or seizures. 1,2,6 Neurologic effects: Sedation is a primary concern with overdose. 8 Hypersalivation can occur.

Poisoning 108
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Unpacking the PEACH Trial: What is Levetiracetam’s Role in Spontaneous Intracerebral Hemorrhage?

RebelEM

Levetiracetam is frequently used to prevent seizures in patients with conditions such as ICH, traumatic brain injury (TBI), supratentorial neurosurgery, and subarachnoid hemorrhage (SAH). About 30% of patients experience early seizures within seven days following the onset of a stroke ( Peter-Derex 2022 ). Article : Peter-Derex et al.

Seizures 123
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Targeted Temperature Management in Paediatric Traumatic Brain Injury

Don't Forget the Bubbles

Therapeutic hypothermia is thought to decrease the brain’s metabolic demand, reduce inflammation and cell death, and reduce the risk of seizures. About PICSTAR PICSTAR is a trainee-led research network open to all doctors, nurses and allied health trainees within Paediatric Intensive Care.

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Return to Learn / Return to Sport after Concussion

Pediatric EM Morsels

In the research setting, abnormalities can be found via functional, blood flow, or metabolic imaging. It does NOT have structural brain damage visible on standard neuroimaging. Mild traumatic brain injury also includes a larger group of injuries that may have evidence of structural injury.

Seizures 281
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The Current Status of Continuous-Seizure Management

ACEP Now

35-year-old man presents by EMS with seizures. According to family at the scene, he has a history of seizures but has not been taking his medication recently. On arrival, he is obtunded, foaming at the mouth, and exhibiting generalized tonic-clonic seizure activity. Clinical Question » How should status epilepticus be diagnosed?

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Cannabidiol in refractory status epilepticus

Don't Forget the Bubbles

A UK-based study found that 4% of admissions to a tertiary paediatric intensive care unit (PICU) over a 10-year period were due to refractory status epilepticus (RSE) – seizures which fail to terminate despite appropriate first and second-line treatments. Despite this, the CFAM still showed ongoing electrical seizure activity.

Seizures 122
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Super Refractory Status Epilepticus

Don't Forget the Bubbles

Four-year-old Fern is a previously healthy girl who presents with a febrile illness and seizures. Seizure activity did not respond to either first or second-line treatments, so she needed rapid sequence induction and transfer to PICU for ongoing anaesthesia and management. What causes Super Refractory Status Epilepticus?

Seizures 111