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The AcT Trial: Tenecteplase vs Alteplase for Acute Ischemic Stroke

RebelEM

Background : Alteplase, a class of medication that converts plasminogen to plasmin leading to fibrin degradation and subsequent clot lysis, has been the standard of care for acute ischemic stroke (AIS) patients that meet eligibility criteria. mg/kg non-inferior to alteplase in the treatment of acute ischemic stroke? vs Alteplase 34.8%

Stroke 135
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The Evolution Of Penetrating Neck Trauma Management – Part 3: Determining Risk

The Trauma Pro

Aerodigestive signs Airway compromise or stridor Bubbles from the wound Significant subcutaneous emphysema Major hematemesis Massive hemoptysis Neurologic signs Neurologic deficits that suggest embolic strokes from a vascular injury Soft signs. Most patients with hard signs will require operative intervention.

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EM@3AM: Stercoral Colitis

EMDocs

Operative management is necessary for signs of peritonitis, evidence of perforation, extensive bowel involvement >40cm, or after failed medical management. 2-4, 6, 8, 9, 12, 13, 14 Operative intervention typically consists of emergency laparotomy with bowel resection, colostomy formation, and Hartmann pouch creation.

EMS 98
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CDC gives a nudge to hospitals on sepsis care

PulmCCM

Fully implemented, CDC’s toolkit would promote sepsis into the major leagues of “code strokes” and “code STEMIs” — highly prioritized system-wide operational programs enjoying executive sponsorship and significant financial and human resources. ” What is that, a sepsis Stasi?

CDC 98
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Remote Consult Protocols for Retinal Artery Occlusion: A Visionary Approach in Emergency Care?

RebelEM

Moreover, there are multiple operational and patient-specific barriers rendering timely thrombolytic administration difficult. What They Did: Retrospective review of consecutive RAO cases managed as part of a remote ophthalmology consult protocol activated on May 1, 2021, at three stroke centers across a health system.

Stroke 85
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ICU Physiology in 1000 Words: The Right Atrial Pressure Does Not Determine Cardiac Output – Part 2

PulmCCM

Kenny MD [ @heart_lung ] In part 1 , right atrial pressure [P ra ] and cardiac output/venous return [CO/VR] were considered as two hemodynamic measures bound at the operating point [OP] of the circulatory system. OP is operating point. Shows what happens when Ppc, Pmsf, Rcardiac and Rvr all vary [grey operating points].

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Journal Feed Weekly Wrap-Up

EMDocs

2022.10.020 #2: TRACE-2 RCT – Tenecteplase vs Alteplase for Stroke Spoon Feed Tenecteplase was non-inferior to alteplase in patients with acute ischemic stroke who were eligible for intravenous thrombolytic therapy but ineligible or refused endovascular thrombectomy. Annals of emergency medicine vol. 81,4 (2023): 453-465. 2023 Feb 12.