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Journal Club - Tranexamic Acid in Trauma

Downeast Emergency Medicine

We know that if administered too rapidly, it can lead to hypotension and other adverse effects including seizures, headaches, backache, abdominal pain, nausea, vomiting, diarrhea, fatigue, pulmonary embolism, deep vein thrombosis, anaphylaxis, impaired color vision, and other visual disturbances.[1] Lastly, the use of TXA is not without risk.

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EM@3AM: Hyperthermia

EMDocs

As you attempt to examine the patient, he has a generalized, tonic-clonic seizure. football players, military). Heat stroke can lead to end-organ dysfunction such as rhabdomyolysis, disseminated intravascular coagulation, cardiogenic shock, liver failure, and cerebral edema. 1 Fever is usually < 40C. Updated 2022 Oct 24].

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TXA (Tranexamic Acid) in PediatricsĀ 

Pediatric EM Morsels

Military Application of Tranexamic Acid in TraumaEmergency Resuscitation (MATTERs) Study. of IV form TXA [O’Neill 2020] Inexpensive ! The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. 2011 Mar26;377(9771):1096-101, 1101.e1-2.