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Coronary Artery Calcium Trial Fails to Impress

Sensible Medicine

Better outcomes, such as fewer heart attacks or strokes, or longer life, is why we interact with healthcare. This was a prospective randomized open-label trial done in 7 hospitals in Australia. Patients were asymptomatic adults who had a first degree relative with CAD before age 60. None of these patients were recommended for statins.

Stroke 87
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The ARAMIS Trial: DAPT vs Alteplase in Minor Nondisabling Acute Ischemic Stroke

RebelEM

Background: Current stroke guidelines recommend IV alteplase for patients with acute ischemic stroke presenting within 4.5hrs of symptom onset based on the NINDS and ECASS III publications. Both NINDS and ECASS III excluded patients with mild stroke symptoms but failed to clearly define a threshold for mild stroke.

Stroke 98
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CDC gives a nudge to hospitals on sepsis care

PulmCCM

The Centers for Disease Control and Prevention formally called on hospitals to develop robust sepsis care programs to systematically identify and treat sepsis, track outcomes, and improve care delivery. Unlike strokes and STEMIs, sepsis has no gold standard for diagnosis. ” What is that, a sepsis Stasi?

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52 in 52 – #38: Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke

EMDocs

This week we cover the EXTEND trial looking at thrombolysis up to 9 hours after stroke onset. and 9 hours of symptom onset; stroke symptoms that started during sleep were assumed to have started halfway between the actual last known well and the time of wake-up. Intervention: Alteplase 0.9 in alteplase group versus 0.9%

Stroke 95
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ECG Blog #435 — Did Cath Show Acute Ischemia?

Ken Grauer, MD

As another alternative consideration — Diffuse ST-T wave abnormalities ( including T wave inversion ) as are seen in ECG #1 could be the result of a non -cardiac condition — including marked metabolic and/or electrolyte disturbance, CNS catastrophe (ie, stroke, intracerebral or subarachnoid bleed, trauma, tumor ), severe anemia, "sick" patient, etc.

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SGEM#269: Pre-Hospital Nitroglycerin for Acute Stroke Patients?

The Skeptics' Guide to EM

Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomized, sham-controlled, blinded, phase 3 trial. While preparing for transport you contemplate administering nitroglycerin due to the likelihood of stroke. The Lancet March 2019. The Lancet March 2019.

Stroke 52
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52 in 52 – #40: DIRECT MT – Endovascular Thrombectomy with or without Intravenous Alteplase in Acute Stroke

EMDocs

Study design: Multicenter open label randomized control trial Enrolled patients from 41 tertiary care hospitals in China Assessing for statistically significant difference in modified Rankin score at 90 days PICO: Population: 206 patients were enrolled with 107 in the intervention group and 99 in the control. hours of stroke onset.

Stroke 86