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Review of the ATHOS 3 trial

Northwestern EM Blog

Mortality benefit is an extremely elusive goal in critical care research 1 but that doesn’t discount the fact that ATHOS 3 wasn’t designed to demonstrate an improvement in any patient-oriented outcome. In my personal practice, I make sure to optimize these and start vasopressin shortly after the initiation of norepinephrine.

Shock 52
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Episode 21- Updates and Controversies in the Early Management of Sepsis and Septic Shock

EB Medicine

Optimal management of septic patients has been a source of intense research, stemming from the landmark study by Rivers in 2001. Also, for research purposes we have to have a common definition, so Sepsis 3 came up with something called the SOFA score. Jeremy, can you give us a little historical context there? So quite a few changes!

Sepsis 40
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Sepsis Updates Relevant to the Emergency Physician

EMDocs

13,14 Fluids Fluid resuscitation is a mainstay of sepsis therapy, as the condition is commonly associated with both absolute and relative hypovolemia. 15 Two changes were elucidated in the 2021 SSC guidelines for fluid resuscitation. Additionally, the recommendation to use a 30 cc/kg bolus was downgraded.

Sepsis 83
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EM@3AM: Takotsubo Cardiomyopathy

EMDocs

Bedside ultrasound shows hypokinesis of the basal portion of the left ventricle with an apparent sigmoid-shaped septum and a dilated inferior vena cava. It was first described in Japan in 1991, where researchers noted a balloon shape to the left atrium resembling a trap used to catch octopuses in Japan. The oral mucosa is moist.

EMS 93
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Venous Congestion in Pediatric Critical Care

Don't Forget the Bubbles

He has had some additional episodes of hypotension post-intubation, which is treated with further volume resuscitation. Before considering a further fluid bolus, you do a point-of-care ultrasound (POCUS). Despite 60ml/kg, his systolic blood pressure is back in the low 50s. How Do We Measure Venous Congestion?

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IV fluids in the ED: When do we really need them?

EMDocs

Over the last few years, however, ultrasound has been increasingly playing an important role in the conversation with multiple studies looking at using ultrasound to predict fluid responsiveness in septic patients – for example, using the velocity time integral with passive leg raise. Tullo et al. Tullo et al. Keijzers, G.,