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Publication Bias and Therapeutic Fashion

Sensible Medicine

It showed that the common practice of using drugs to suppress rhythm disturbances (anti-arrhythmics) in patients after heart attack (myocardial infarction) led to higher death rates. CAST shocked the world of cardiology because suppression of rhythm disturbances after MI had been an accepted practice. But our belief was wrong.

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Episode 24 - First Trimester Pregnancy Emergencies: Recognition and Management

EB Medicine

Interestingly, groups have examined outpatient care with 2 days of daily IM ceftriaxone vs inpatient IV antibiotic therapy and they found that there may be a higher than acceptable risk in the outpatient setting as several required eventual admission and one developed septic shock in their relatively small trial.

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Episode 32 - Assisting With Air Travel Medical Emergencies: Responsibilities and Pitfalls (Ethics CME)

EB Medicine

Nachi: AEDs are also required and have been since 2001 and amazingly when a shock was delivered in flight, 40% survived to hospital discharge with a good outcome. Over the past 3 years, we’ve thoroughly enjoyed hosting EMplify and having the unique opportunity to share high quality evidence based medicine with you all.

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PROFID EHRA: The Most Important Trial of the Decade in Cardiology

Sensible Medicine

Yet, still, the vast majority (≈13 of 14) of patients implanted with an ICD for primary prevention never receive a shock, and therefore gain no benefit. Keep in mind that the ICD is a dumb device—as it saves lives by shocking a malignant arrhythmia back to normal. Plus, it’s in mortality, not a composite endpoint.