Tue.Jan 28, 2025

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Direct Oral Anticoagulant (DOAC) Reversal: Part 3

The Trauma Pro

In my last two posts, I reviewed some older papers on the efficacy of Andexxa (andexanet alfa) for the reversal of Factor Xa inhibitor anticoagulants. Those results were not very impressive, especially considering the high cost of this drug. In 2021, an article was published (reference 1) that performed a systematic review of the literature from 2017 to 2020.

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Is RFK Jr to blame for the Samoa measles outbreak? An empirical analysis of published scholarly papers and news stories

Sensible Medicine

Just out, we have a new paper on a provocative question. What factors were blamed for the 2019 Samoa measles outbreak in the peer reviewed literature and news coverage? At the time, and now 5 years later? Subscribe now First, we assembled every single peer reviewed article and mainstream media news story on the Samoa measles outbreak. 163 studies met our criteria.

Academics 105
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A 34 yo Man with chest pain and Zero ST Elevation

Dr. Smith's ECG Blog

Written by Hans Helseth A 34 year old man with no known medical history presented to the ED after an hour of chest pain. He described the pain as a mid sternal "burning sensation" and rated it 8.5 out of 10 at onset, but on presentation to the ED, reported that the pain had improved to 4.5. His first EKG is shown below, with a lead II rhythm strip: EKG 1, 1645 A provisder who is looking for STEMI would not see much in this EKG.

EKG/ECG 73
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EM Quick Hits 62 Optimizing RSI Medication Timing, ED Boarding of Older Patients, Prolonged Tourniquet Use, Rural Peer Support Programs, ECG Reciprocal Changes, Nutrition Tips for Shift Workers

Emergency Medicine Cases

On this month's EM Quick Hits podcast: Anand Swaminathan on optimizing RSI medication timing, Brittany Ellison ED boarding challenges in older patients and solutions to ED crowding and flow, Dave Jeromeon managing prolonged tourniquet application, Nour Khatib and Phil Gillick on a rural peer support case, Jesse McLaren on ECG reciprocal changes in acute coronary occlusion, and Melody Ngon practical nutrition tips for shift workers.

EMS 79
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Well Well Well, We Want Them Infected Doctors Are OK With Censorship After All

Science Based Medicine

Doctors who mourned the loss of a single speech or YouTube video are fine with the the mass censorship of public scientists. The post Well Well Well, We Want Them Infected Doctors Are OK With Censorship After All first appeared on Science-Based Medicine.

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Pretibial Lacerations

Mind The Bleep

Pretibial lacerations are common injuries, especially among older adults, because the skin over the shin becomes thinner and more susceptible to tears with age. Epidemiology Pretibial lacerations may occur following minor trauma to the shin area, particularly in elderly individuals with fragile skin. The prevalence of these injuries is estimated at 5.2 per 1000 emergency department attendances in the UK (1).

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Hypoxia as a medicine

The Evolution & Medicine Review

Oxygen is essential for human life, yet a growing body of preclinical research is demonstrating that chronic continuous hypoxia can be beneficial in models of mitochondrial disease, autoimmunity, ischemia, and aging. This research is revealing exciting new and unexpected facets of oxygen biology, but translating these findings to patients poses major challenges, because hypoxia can be dangerous.

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ECG of the week 29/1/2025

EMergucate

An 86yr male presents with syncope and melena. Hb 76. His ECG is below: What is the Rythm? What is you management plan for this patient?

EKG/ECG 52