Mon.Feb 17, 2025

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A new, costly cancer drug vs placebo; Cabozantinib in neuroendocrine tumors; How NIH funded trials can fail patients and payers

Sensible Medicine

John is sick, so I have big shoes to fill. Today’s study of the week is a cancer trial. I know many of you aren’t cancer doctors, and you are thinking about skipping this essay. Let me assure you: you will learn something. The trial has issues with control arm, skewed randomization (2:1), drop out and endpoints. It is a rollercoaster ride of critical appraisal.

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Boosting blood pressure in critically ill patients is not always wise

The Evolution & Medicine Review

By Joe Alcock Many advances in the care of critically ill patients over time have involved intervening less aggressively. A recent perspective by DAmico and colleagues (1) builds on that tradition of less is more. In Protective Hemodynamics: C.L.E.A.R.! the authors urge caution in treating low blood pressure with fluids or vasopressor medications. DAmico, F.

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PEERLESS: Interventional therapies for pulmonary embolism

First 10 EM

The decision between mechanical thrombectomy and catheter directed thrombolysis for pulmonary embolism is not one that most emergency physicians are making. Most (like me) probably dont even have access to such therapies, which might be a good thing, as both therapies remain completely unproven. However, I thought I would share the PEERLESS trial as a […] The post PEERLESS: Interventional therapies for pulmonary embolism appeared first on First10EM.

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How long should CPR be performed after cardiac arrest in the hospital?

PulmCCM

Cardiopulmonary resuscitation (CPR) is performed on more than 250,000 people in U.S. hospitals each year. When a patient is failing to recover spontaneous circulation, the clinician in charge must decide whether and when to cease resuscitation efforts. Moments after he or she says “stop,” the person will be declared legally dead. It’s an awesome and humbling responsibility, the ultimate life-and-death decision.

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ECG Cases 54 The Art of Occlusion MI: Scale and Proportionality

Emergency Medicine Cases

On this month's ECG Cases, Dr. Jesse McLaren explains how STEMI criteria can be false positive with large scale QRS and proportional ST elevation, or false negative with low/normal scale QRS and disproportionate ST elevation and hyperacute T waves, and that rules for subtle occlusion using proportionality can help differentiate LBBB with or without Occlusion MI, or LV aneurysm vs anterior STEMI with Q waves.

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On the Other Site …

EM Literature of Note

Ive taken the opportunity of reboot to try and make smaller, more digestible chunks to highlight what Im reading and to post more often. So, check out: The Journavx Hype Predicting Heart Failure from ECGs Whats the Best Fluid for Pancreatitis? A Nice Win for Radiology AI Where Endovascular Treatment Fails Even the Best Make Terrible Alerts The Future of AI is FUTURE-AI?

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Liver Service Transfer / Referral

Life in the Fast Lane

John Currie Liver Service Transfer / Referral Remember the 3s and EncephalopaTHREE (ph 7.3, INR>3, BSL of 3.

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Medical Music Mondays: Beneath the Surface

PEMBlog

Cellulitis is like an infection of the icing – if you imagine the skin as a piece of cake that it. Treat with cephalexin – red, hot, swollen, and tender – and sometimes fever and systemic symptoms. I could’ve wrote a song about erysipelas but it doesn’t rhyme with anything. Lyrics Fast spreading and red I hope I’m not dead don’t want to be bacteremic from just my skin red, hot, swollen, and tender skin infection, not a life ender cephalexin is the first

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Mastering ADLs Training for Healthcare Providers

American Medical Compliance

Activities of Daily Living (ADLs) are essential tasks that individuals perform every day to maintain their independence. For healthcare providers, understanding and supporting patients’ ability to perform these tasks is a critical aspect of providing compassionate care. This course is designed to equip healthcare professionals with the knowledge and skills necessary to assess, support, and optimize patients’ ADLs.

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Venous Congestion in Pediatric Critical Care

Don't Forget the Bubbles

Two-liner A look at the evolving concept of venous congestion and the haemodynamic assessment in critically ill children and adults. The literature exploring its nuances continues to grow in adults but remains poorly understood in paediatric populations.[1] Fred is a 3-year-old boy who presents to the emergency department. He was previously healthy and presented with a 3-day history of cough, fevers, low appetite, and decreased energy.

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So it begins: Robert F. Kennedy Jr. is confirmed as HHS Secretary and immediately starts dismantling US federal science infrastructure

Science Based Medicine

The nightmare has come true. Robert F. Kennedy Jr. has been confirmed as HHS Secretary and didn't wait long to start dismantling federal science and health programs. The White House even formed a "MAHA commission" to draw up a battle plan. The post So it begins: Robert F. Kennedy Jr. is confirmed as HHS Secretary and immediately starts dismantling US federal science infrastructure first appeared on Science-Based Medicine.

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