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REBEL Cast Ep116: The CLOVERS Trial – Restrictive vs Liberal Fluids in Sepsis-Induced Hypotension

RebelEM

Background: IV fluids are part of the standard resuscitation bundle in septic shock, however it is unclear if they provide a significant benefit. The goal of the trial was to see if early vasopressors improved shock control by 6 hours. This resulted in better shock control by 6hrs (76.1% Liberal: 14.9% Liberal: 14.9%

Sepsis 100
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REBEL Cast Ep114: High Flow O2, Suspected ACS, and Mortality?

RebelEM

Click here for Direct Download of the Podcast Paper: Stewart, RAH et al. However, this was not the primary outcome of this trial and no definitive conclusions can be drawn. Based on recent studies, current guidelines recommend that O2 should not be given to non-hypoxemic patients with STEMI or NSTEMI [2,3]. Low O2 protocol: 3.1%

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Journal Club - Tranexamic Acid in Trauma

Downeast Emergency Medicine

4] We also know that severe TBI is commonly associated with the development of intracranial hemorrhage where the presence and volume of blood are associated with increased mortality and poor outcomes.[5] Association between prehospital tranexamic acid administration and outcomes of severe traumatic brain injury. JAMA Neurol.

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COVID STEROID 2 Trial Investigates Dexamethasone 6 mg or 12 mg in COVID-19

PulmCCM

The primary outcome was the number of days alive without life-support – defined as invasive mechanical ventilation, circulatory support or renal replacement therapy – at 28 days post randomization. Download his free textbook here. days [p = 0.07] in absolute terms. versus 27.1% versus 32%, respectively.

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Back to the BaSICS: does the infusion rate of a fluid bolus affect mortality?

PulmCCM

The primary outcome was 90-day survival. Secondary outcomes included: the need for kidney replacement therapy up to 90 days; acute kidney injury defined as the progression KDIGO stage 0 or 1 at enrollment to at least 2 at days 3 and 7; SOFA score; and the number of days not requiring mechanical ventilation within 28 days.

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Cardiac Rhythms/ECG Module

Don't Forget the Bubbles

For anyone approaching a structured ABC would be a priority to establish whether shock was present or not. Typical features include: HR >220bpm Narrow complex regular tachycardia P waves difficult to identify In this case there is no shock present so we can proceed to the right branch of the ALSG guideline.

EKG/ECG 98
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REBEL Cast Ep 118: The PROCOAG Trial – 4F-PCC for Trauma Patients?

RebelEM

Interventions such as early application of hemorrhage control, tranexamic acid, reduction of crystalloid fluid administration and balanced ratio blood product transfusion have improved many patients’ outcomes. Click here for Direct Download of the Podcast Paper: Bouzat P et al. Severe acute traumatic coagulopathy = PT >1.5