article thumbnail

The AcT Trial: Tenecteplase vs Alteplase for Acute Ischemic Stroke

RebelEM

Reliance on research coordinators to accurately determine mRS scores over a telephone interview could suffer from issues of reliability. Additionally, more research and future studies are needed to show superiorly or reproduce these results in regard to thrombolytic agents. mg/kg, max 25mg) vs. intravenous alteplase (0.09

Stroke 134
article thumbnail

Best Of AAST #7: How Do You Like Your Platelets – Warm Or Cold?

The Trauma Pro

Until the last few years, massive transfusion in trauma consisted of component therapy, an admixture of packed red cells, plasma, and platelets. Whole blood transfusion is making inroads again, but it is used in a minority of centers. They identified soldiers who received either room-temperature or cold-stored platelets.

Military 113
Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Trending Sources

article thumbnail

Grand Rounds Recap 7.31.24

Taming the SRU

to teach you and your learner something new on shift skin adhesives WITH dr. hill Dermabond is a polymer (octyl cyanoacrylate) that can be used to repair lacerations in the Emergency Department faster than sutures, allowing the ED physician to be more efficient.

article thumbnail

Bilious Vomiting in the Neonate

Mind The Bleep

Increased risk in growth restricted infants, premature babies, maternal drug abuse, formula fed babies, infants receiving blood transfusions. Advances in Paediatric Research. Age at Onset: Typically presents around 2-3 weeks old but can present earlier or later than this. American Family Physician , 2791-2798. Parikh NS, I.

Sepsis 52
article thumbnail

Are we on the right TRACT? 

Don't Forget the Bubbles

Transfusion Decisions in Severe Anaemia Reducing child mortality remains high on the global health agenda. Let’s take the humble blood transfusion – used in emergency departments across the globe and playing a key role in critical care. However, there is a huge variation in transfusion practice globally. N Engl J Med.

article thumbnail

Good To Know: April 10, 2025

PulmCCM

Almeida et al Crit Care Med 2025 ) They did have more major bleeding (10% vs 1%), often requiring blood transfusions. A flawed clinical construct (“ICU delirium”) that’s also easy to use (nurses do the CAM-ICU assessments) can produce enough research to fill entire library aisles. But is anything being learned?

CDC 40
article thumbnail

CRYOSTAT-2: Early Empiric Cryoprecipitate in Major Trauma

RebelEM

This would normally make me worry about dilution of results and biasing the results to the null hypothesis, but in the per protocol analysis (170 patients excluded from the full cohort, due to no longer requiring blood transfusion, dying within 90 minutes of arrival or being randomized in error) didn’t seem to affect this result either.