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Understanding pre-hospital blood transfusion decision-making for injured patients: an interview study

Emergency Medicine Journal

Background Blood transfusion for bleeding trauma patients is a promising pre-hospital intervention with potential to improve outcomes. However, it is not yet clear which patients may benefit from pre-hospital transfusions. The last theme focuses on the issues with decision-making itself.

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The AcT Trial: Tenecteplase vs Alteplase for Acute Ischemic Stroke

RebelEM

Limitations : Open label study design Outcome assessments were done via telephone interview. mg/kg, max 25mg) vs. intravenous alteplase (0.09 mg/kg followed by 0.81 vs Alteplase 34.8% Unadjusted risk difference 2.1% [ 95% CI -2.6 mg/kg, max 25mg) vs. intravenous alteplase (0.09 mg/kg followed by 0.81 vs Alteplase 34.8% mg/kg followed by 0.81

Stroke 135
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Trauma Resuscitation Updates

RebelEM

vs 3U) but no difference in mortality (Study not powered for this outcome) Clinical Take Home Point: The use of vasopressors is controversial and requires a nuanced approach SUMMARY OF MINIMIZING IATROGENIC INJURY RESTORE PERFUSION VOLUME REPLACEMENT Blood Products >>> Crystalloids Holcomb JB et al. NEJM 1994. [2]

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The Quandary of a "Positive" Trial with a Non-significant Result?

Sensible Medicine

But, in general, blood transfusion strategies have been studied in many other clinical situations. A Cochrane review of trials of more than 21K patients have shown that restrictive strategies have led to a 50% decreased use of blood without differences in morbidity or mortality. That makes sense. I am not sure why.

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CRYOSTAT-2: Early Empiric Cryoprecipitate in Major Trauma

RebelEM

This could dilute any beneficial effects seen Lack of blinding may bias results (Although mortality is a solid objective primary outcome, bias may still creep in terms of management) Discussion: Authors were looking for an absolute mortality difference of 7% from baseline mortality of 26% with a 90% power. Cryoprecipitate Group: 25.3%

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ToxCard: Iron

EMDocs

7 Workup other than serum iron concentration at 4 hours after ingestion not shown to accurately predict clinical outcomes or severity of toxicity. Blood transfusion for clinically significant blood loss. Iron Ingestion: an Evidence-Based Consensus Guideline for Out-of-Hospital Management. Antiemetics as needed.

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The Latest in Critical Care, 1/8/23 (Issue #24)

PulmCCM

Smaller blood-collection tubes to reduce red blood cell transfusion (STRATUS trial) Cumulatively, daily labs on hospitalized patients deplete substantial volumes of blood, almost all of which is wasted. They have a less-powerful vacuum that removes about half as much blood per tube.