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Outcome: No statistically significant difference in primary outcome, which was absence of clinically apparent seizures without the need for additional anti-convulsant medications AND improving responsiveness at 60 minutes after the start of trial-drug infusion, as determined by the treating physician.
Due to its extremely high morbidity and mortality as well as high healthcare costs, the prompt recognition, diagnosis and resuscitation of shock is key. To reverse these effects as well as refractory hypotension, hydrocortisone is the preferred agent due to both its glucocorticoid and mineralocorticoid properties. 2) Boyd J, Walley K.
antibiotics, NSAIDs) Acute urticaria with angioedema or anaphylaxis provided that urticaria was still present after initial treatment and alleviation of anaphylaxis symptoms. Exclusion: Presented with acute anaphylaxis, and their acute anaphylactic symptoms had not yet been treated.
BASICS responders have additional skills and can provide pre-hospital emergency care to patients delivering time-critical interventions to improve outcomes. This is also based on where you live and what resources are already available, as well as how you get on with your PHECC. What is a BASICS responder and who can do it?
Though this disorder is routinely treated with medications for anaphylaxis (i.e. There is no well-established treatment algorithm other than airway control if the angioedema is severe and appears to be causing a mechanical obstruction and cessation of the medication. Reference: Sinert et al. J Allergy Clin Immunol Pract 2017.
Managing pain in these patients is notoriously challenging but essential to prevent complications, facilitate physiotherapy, and improve outcomes. ED Physicians are already well-versed in the use of ultrasound. These blocks were administered as single-shot injections or through catheter insertion for continuous infusion.
Primary outcome was discharge to home at 24 hours. mcg/kg/min Can increase dose q30 min to max dose of 10 mcg/kg/min Can cause elevations in troponin If there hasn’t been improving, consider IM epinephrine instead Same as anaphylaxis dose 0.01 mg inhaled over the first hour of therapy Followed by 0.5 final FEV1 was 51.1%
4] We also know that severe TBI is commonly associated with the development of intracranial hemorrhage where the presence and volume of blood are associated with increased mortality and poor outcomes.[5] Association between prehospital tranexamic acid administration and outcomes of severe traumatic brain injury. JAMA Neurol.
You may have heard of the recommendations for incision / excision, use of venom extraction devices, tourniquets, chill methods and even electroshock therapy – well these methods are all OUT. Nachi: Not only are they out, they actually worsen outcomes, so definitely don’t pursue any of them.
In some individuals, the urushiol can result in anaphylaxis (Type I hypersensitivity reaction) Treatment Soothing measures Oral antihistamines Topical corticosteroids Nicotinic toxins Mechanism: Over-stimulates nicotinic receptors Acts as an agonist at nicotinic acetylcholine receptors in the sympathetic and parasympathetic nervous systems, as well (..)
randomization) as per protocol (i.e. eligibility to screened ratio) Feasibility of recruitment defined as proportion of patients consenting to participate in the study protocol from eligible patients (i.e. randomization) as per protocol (i.e. randomization) as per protocol (i.e.
The loss of these cells leads to immunosuppression as well as decreased responsiveness of the immune system as a whole Patients with neutropenia will not only get very sick very quickly, but also will have blunted immune response and may not localize signs of infection well Fever or malaise may be their only presenting symptoms.
It should be made based on a balance between risk of thromboembolic events vs recurrent bleeding (risk-benefit), as well as cost-benefit. Ultimately, patients with variceal bleeding require endoscopic variceal ligation (EVL) but it is important to understand what therapies should be initiated promptly in the ED to improve overall outcomes.
for detecting major injuries Abnormal CXR Rapid deceleration mechanism Presence of a distracting injury Chest wall tenderness Sternal/thoracic spine/scapular tenderness There are limited decision-making rules for thoracic spine imaging Yet a study (Inaba et al., 2015) reported a sensitivity of 98.9%
Well, a lot of people out there are actually refusing vitamin k for their newborns. Well, families state that they have concerns about the preservative in the injection, maybe that it could cause autism. A potential for adverse reactions to an injection like anaphylaxis. So why am I covering this topic? It doesn’t.
PMID: 39578750 Bottom line: This is a well done observational study that demonstrates an association between cell phone use and disposition to home, but I think the complexity really highlights the difficulty of making strong conclusions from observational data, and I cant imagine that this data is at all helpful clinically. (I 2024 Oct 9.
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