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ToxCard: Second Generation Antipsychotic Overdose

EMDocs

1,2 Neuroleptic malignant syndrome (NMS) (hyperthermia, autonomic instability, rigidity, altered mental status [AMS]) can occur as well and is most often seen with clozapine but has been observed with other atypicals. Rigidity and hyperthermia should raise concerns for NMS. 1 Seizures may occur due to lowered seizure threshold.

Poisoning 108
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Dantrolene for Malignant Hyperthermia

Resus Review

Malignant hyperthermia is a life-threatening reaction to volatile anesthetics and the neuromuscular blocking agent succinylcholine. Dantrolene acts at the ryanodine receptor blocking the release of calcium from the sarcoplasmic reticulum, and reducing the intracellular calcium, thereby countering the effects of the malignant hyperthermia.

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Neurogenic Shock in Children

Pediatric EM Morsels

Shunting of blood to the extremities results in thermal dysregulation and subsequent hypothermia. Crystalloid may help, but neurogenic shock may not respond to fluid administration. Unopposed vagal tone leads to bradycardia. Alpha 1 agonists are necessary to maintain appropriate blood pressure.

Shock 304
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emDOCs Podcast – Episode 102: Hypocalcemia in Trauma and the Diamond of Death

EMDocs

Previous triad of death = hypothermia, acidosis, and coagulopathy. Liver dysfunction, secondary cirrhosis, critical illness, trauma, and hypothermia reduce citrate metabolism. Hypothermia also leads to hypoCa. Prehospital Ca administration reduces risk of hypoCa on arrival (70% vs. 28%). Target an ionized Ca level over 1.2

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Hypothermic Cardiac Arrest: Pearls and Pitfalls

EMDocs

Some authors recommend not starting chest compressions in hypothermia unless there is no organized cardiac activity (e.g., 2 In reality you may start compressions before you confirm that hypothermia was the primary cause of cardiac arrest. Obtaining a core temperature early in any arrest suspected to be from hypothermia is key.

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2023 AHA Update on Management Cardiac Arrest or Life-Threatening Toxicity Due to Poisoning

EMDocs

Naloxone administration may reverse respiratory arrest, preventing progression to cardiac arrest. Standard advanced life support with the addition of administration of sodium bicarbonate is appropriate for the treatment of life-threatening dysrhythmias caused by cocaine or other sodium channel blockers. COR 2a, LOE B-NR.

Poisoning 112
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ToxCard: Anticholinergic Plant Toxicity

EMDocs

3-6 Clinical Presentation: Symptoms include altered mental status, tachycardia, hyperthermia, urinary retention, mydriasis, blurred vision, dry skin, hallucinations. Anticholinergic toxicity has overlap with other toxicological causes of hyperthermia which are reviewed here: Hyperthermia in the Toxicological Setting.