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The PROPHY-VAP Trial: Ceftriaxone to Prevent VAP in Patients with Acute Brain Injury

RebelEM

Discussion In patients with brain injury who required ICU admission and mechanical ventilation, the PROPHY-VAP trial found that early administration of a single dose of ceftriaxone decreased the risk of VAP, exposure to ventilation, exposure to antibiotics, prolonged ICU and hospital stay, and mortality, with no safety concerns.

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