RebelEM

FEBRUARY 1, 2024

Tenecteplase, a modified version of alteplase, is being increasingly utilized for AIS due to its favorable pharmacological profile, ease of administration, and cost effectiveness. Reliance on research coordinators to accurately determine mRS scores over a telephone interview could suffer from issues of reliability. vs Alteplase 34.8%

Stroke 134

Stroke Blood Transfusions Outcomes EMS 134

The Trauma Pro

SEPTEMBER 20, 2023

Until the last few years, massive transfusion in trauma consisted of component therapy, an admixture of packed red cells, plasma, and platelets. Whole blood transfusion is making inroads again, but it is used in a minority of centers. They identified soldiers who received either room-temperature or cold-stored platelets.

Military 113

Military Blood Transfusions Administration Outcomes 113

RebelEM

OCTOBER 30, 2023

Most major hemorrhage protocols give a balanced transfusion of PRBCs, FFP, and platelets in ratios approaching concentrations found in whole blood. The optimal approach to fibrinogen administration in massive hemorrhage protocols is unknown. Fibrinogen products may also be needed to stabilize clots and stem bleeding.

Administration 127

Administration Blood Transfusions Outcomes Hospitals 127

RebelEM

JUNE 19, 2023

The PATCH-trauma researchers sought to address this critique. PMID: 37314244 Clinical Question: In advanced trauma systems, does prehospital administration of TXA increase the rate of survival with a favorable neurologic outcome in patients at risk for trauma-induced coagulopathy? Prehospital Tranexamic Acid for Severe Trauma.

Blood Transfusions 105

Blood Transfusions Outcomes Administration Hyperthermia / Hypothermia 105

Northwestern EM Blog

JANUARY 24, 2022

At those levels, bicarbonate administration has not been shown to improve cardiac output, MAP or pressor response. For example, a patient in cardiogenic shock will likely worsen with the administration of fluids and the wrong vasopressors. Critical Care Research and Practice. Alternate Shock Not all shock is declared equal.

Anaphylaxis 52

Anaphylaxis Shock Sepsis Resuscitation 52

Downeast Emergency Medicine

APRIL 26, 2021

2][3] If earlier treatment with TXA is better, would there be benefit in its administration in the prehospital setting? Association between prehospital tranexamic acid administration and outcomes of severe traumatic brain injury. Blood Coagul Fibrinolysis. If so, could this be done safely? JAMA Neurol. 2021;78(3):338–345.

Head Injuries 52

Head Injuries Administration Outcomes Seizures 52

EB Medicine

OCTOBER 1, 2018

Optimal management of septic patients has been a source of intense research, stemming from the landmark study by Rivers in 2001. Also, for research purposes we have to have a common definition, so Sepsis 3 came up with something called the SOFA score. Jeremy, can you give us a little historical context there? Nachi : What a struggle.

Sepsis 40

Sepsis Shock Fluid Resuscitation Hospitals 40