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When Studies Can't Answer an Important Question (but are still published)

Sensible Medicine

Surgeons can operate on TR to either repair or replace the valve. But it’s a tough operation with high risk to the patient. Design of the Experiment: An important question in cardiology is if and when to operate on patients with TR. Sham operations are tough to do because of the ethical challenges.

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Hydroxycobalamin vs Methylene Blue for Vasoplegic Shock from Cardiopulmonary Bypass

RebelEM

Background Information: Vasoplegic shock is defined as hypotension with normal or increased cardiac output and can commonly occur in post-cardiac surgery patients having received cardiopulmonary bypass. Hydroxocobalamin Versus Methylene Blue for the Treatment of Vasoplegic Shock Associated With Cardiopulmonary Bypass. 2023 Jul 19.

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Sniffing out Sepsis - Vibes vs Scoring Systems?

Taming the SRU

National campaigns to improve sepsis care, namely the Centers for Medicare and Medicaid Services’ introduction of “Severe Sepsis and Septic Shock Early Management Bundle”, have faced many challenges in physician and provider adherence. Sepsis as a disease process has been difficult to both clearly define and quickly recognize.

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The Safety and Efficacy of Push Dose Vasopressors in Critically Ill Adults

RebelEM

Nontraumatic hypotension and shock in the emergency department and the prehospital setting, prevalence, etiology, and mortality: a systematic review. PMID: 36108346 Clinical Question: What is the efficacy and safety of peripherally administered push dose pressors for the treatment of acute hypotension? 2006;130(4):941–6. 2015;10(3):e0119331.

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Impact of Emergency Department Crowding on Lung Protective Ventilation

RebelEM

What They Did: Retrospective, observational cohort study in a single high-volume academic hospital The ED had a 5 bed area used for ongoing management and resuscitation of patients who clinically deteriorate while boarding or while actively undergo a workup in other sections of the ED. J Crit Care.

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Is it Time to Take Another Look at the State of Emergency Care in the U.S.? 

ACEP Now

Dr. Prescott, currently retired, was Chief Academic Officer of the Association of American Medical Colleges from 2008-2021 where he says he worked with “every single school of medicine in the U.S.,” National Academics. There was no center at the NIH that looks at emergency care as a specialty.” Accessed August 21, 2023.

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Multisystem Trauma in Children, Part Two: Massive Transfusion, Trauma Imaging, and Resuscitative Pearls

Pediatric Emergency Playbook

On arrival, he was in compensated shock, with tachycardia. Fox et al in Academic Emergency Medicine found a sensitivity of 52%; with a 95% confidence interval [CI] = 31% to 73%. Often children even with high-grade splenic and liver lacerations can be managed non-operatively. He decompensates and needs blood.