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SGEM#468: Wide Open Monocytes – Using MDW to Diagnose Sepsis

The Skeptics' Guide to EM

Monocyte distribution width (MDW) as a screening tool for early detecting sepsis: a systematic review and meta-analysis. Clinical Chemistry and Laboratory Medicine 2022; 60(5):786-792 Clin Chem Lab Med. Background: Rapid and accurate diagnosis of sepsis is critical, as early intervention can significantly reduce patient mortality.

Sepsis 60
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Pre-Hospital Antibiotics in Sepsis?

RebelEM

Background: Sepsis remains one of the leading causes of morbidity and mortality. Prehospital Administration of Broad-Spectrum Antibiotics for Sepsis Patients: A Systematic Review and Meta-Analysis. Health Sci Rep 2022. It is well-established that earlier recognition and treatment can lead to better outcome for these patients .

Sepsis 132
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Quality initiative to improve emergency department sepsis bundle compliance through utilisation of an electronic health record tool

EM Ottawa

2022 Jan;11(1):e001624. Questions and Methods: Using a cohort and QI approach, to demonstrate the effectiveness of a multidisciplinary educational intervention and EHR tool to increase sepsis bundle compliance. Methodology: 2/5 Usefulness: 3/5 Warstadt NM, et al. BMJ Open Qual. Findings: Overall EHR tool use increased from 23.3

Sepsis 98
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An Herbal Hope: Is XBJ A Game-Changer in Sepsis Management?

RebelEM

Background: Could Xuebijing (XBJ) catalyze a paradigm shift in sepsis management? XBJ is an herbal compound used in China to manage various inflammatory and infectious processes in recent years, including sepsis. This post evaluates the recent “Efficacy of Xuebijing Injection in Patients With Sepsis (EXIT-SEP)” trial.

Sepsis 98
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EM@3AM: Stercoral Colitis

EMDocs

Clinical exam: 2, 3, 9 Abdominal distension and tenderness Nausea and vomiting Stool present in the rectal vault Peritonitis may be accompanied by hemodynamic instability in the case of sepsis. 2-4, 6 If there is a concern for perforation or sepsis, surgical consultation, blood cultures, empiric antibiotics, and fluids are recommended.

EMS 98
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Rebaked: Inborn Errors of Metabolism presenting in the ED

Pediatric EM Morsels

Pediatr Rev (2022) 43 (7): 371–383. Incidence of inborn errors of metabolism in British Columbia, 1969–1996. Pediatrics. 2000; 105:e 10. Inborn Errors of Metabolism: Becoming Ready for Rare. Samantha A. Schrier Vergano. link] The post Rebaked: Inborn Errors of Metabolism presenting in the ED appeared first on Pediatric EM Morsels.

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But Can You Just PO?

Taming the SRU

There is substantial evidence that IV fluids can be beneficial in patients with sepsis complicated by hypotension and labor. 2022 Sep 11;5(5):e827. Patients receiving maintenance fluids are hemodynamically stable, but they are unable to orally meet their daily fluid and electrolyte requirements. Health Sci Rep. doi: 10.1002/hsr2.827.