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Long-Term Outcomes in Patients Using Protocol-Directed Active Surveillance for Prostate Cancer

Sensible Medicine

In this context, the Canary Prostate Active Surveillance Study ( PASS ) sought to understand the long-term outcomes of active surveillance. Question What are the long-term outcomes for patients with favorable risk prostate cancer managed with protocol-directed active surveillance? The cohort enrolled patients from 2008 to 2022.

Outcomes 101
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Anti-NMDA Receptor Encephalitis in Children and Adolescents

Pediatric EM Morsels

Higher titers in both CSF and serum were associated with poor outcomes. Earlier diagnosis leads to better outcomes. Younger Age at Onset Is Associated With Worse Long-term Behavioral Outcomes in Anti-NMDA Receptor Encephalitis. 2022 Jul 6;9(5):e200013. It is best to assume the worst and cover for this possibility.

Seizures 269
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Is emergency doctors tolerance of clinical uncertainty on a novel measure associated with doctor well-being, healthcare resource use and patient outcomes?

Emergency Medicine Journal

We aimed to develop a UT measure and assess associations with doctor-related factors (eg, experience), patient outcomes (eg, reattendance) and resource use (eg, episode costs). Methods From May 2021 to February 2022, emergency doctors (specialty trainee 3 and above) from five Yorkshire (UK) departments completed an online questionnaire.

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Neurogenic Shock in Children

Pediatric EM Morsels

Updated 2022 Feb 10]. Orenstein JB, Klein BL, Gotschall CS, Ochsenschlager DW, Klatzko MD, Eichelberger MR. Age and outcome in pediatric cervical spine injury: 11-year experience. Updated 2022 Mar 3]. Tenenbein M, Macias CG, Sharieff GQ, et al, eds. In: Strange and Schafermeyer’s: Pediatric Emergency Medicine. 5 th Edition.

Shock 300
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Cerebral Edema and Diabetic Ketoacidosis: Rebaked

Pediatric EM Morsels

Factors associated with adverse outcomes in children with diabetic ketoacidosis-related cerebral edema. ISPAD Clinical Practice Consensus Guidelines 2022: Diabetic ketoacidosis and hyperglycemic hyperosmolar state. 2022; 23( 7): 835- 856. Is your patient hyperglycemic, acidotic, with ketonuria? Then we’ve likely got DKA.

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Trauma Resuscitation Updates

RebelEM

vs 3U) but no difference in mortality (Study not powered for this outcome) Clinical Take Home Point: The use of vasopressors is controversial and requires a nuanced approach SUMMARY OF MINIMIZING IATROGENIC INJURY RESTORE PERFUSION VOLUME REPLACEMENT Blood Products >>> Crystalloids Holcomb JB et al. NEJM 1994. [2]

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Pre-Hospital Antibiotics in Sepsis?

RebelEM

It is well-established that earlier recognition and treatment can lead to better outcome for these patients . Health Sci Rep 2022. Three outcomes were evaluated, with none being deemed the primary outcome. Health Sci Rep 2022. Background: Sepsis remains one of the leading causes of morbidity and mortality.

Sepsis 129