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Can acetaminophen improve outcomes in sepsis?

PulmCCM

The ASTER Trial Ware et al conducted a phase 2b randomized trial from 2021 to 2023 among 447 patients admitted with sepsis and organ failure at 40 US academic hospitals. Patients received either 1 g of acetaminophen IV every six hours or placebo for five days.

Sepsis 52
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CCEDRRN Infographic: Patient-reported health outcomes of SARS-CoV-2

Canadian EM

Although some COVID-19 survivors report persistent symptoms months after resolution of the acute infection, we do not know much about their long-term physical and psychological health outcomes. 1​ We used data from 22 CCEDRRN EDs across 5 provinces between March 2020 to July 2021.

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Role of hospital strain in determining outcomes for people hospitalised with COVID-19 in England

Emergency Medicine Journal

This study aimed to examine the association between COVID-19-related hospital bed-strain during this time and patient outcomes. In-hospital mortality was the primary outcome of interest and length of stay a secondary outcome. Methods This was a retrospective observational study using Hospital Episode Statistics data for England.

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SGEM Xtra: Dogmalysis 2021

The Skeptics' Guide to EM

Date: February 19th, 2021 This is an SGEM Xtra episode. I had the honour of presenting at the Lehigh Valley Health Network Grand Rounds on February 4th, 2021. Date: February 19th, 2021 This is an SGEM Xtra episode. I had the honour of presenting at the Lehigh Valley Health Network Grand Rounds on February 4th, 2021.

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The RELIEF feasibility trial: topical lidocaine patches in older adults with rib fractures

Emergency Medicine Journal

Feasibility outcomes were recruitment, retention and adherence. Clinical end points (pulmonary complications, pain and frailty-specific outcomes) and patient questionnaires were collected to determine feasibility of data collection and inform health economic scoping. Pain and some frailty-specific outcomes were not feasible to collect.

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Anti-NMDA Receptor Encephalitis in Children and Adolescents

Pediatric EM Morsels

Higher titers in both CSF and serum were associated with poor outcomes. Earlier diagnosis leads to better outcomes. Younger Age at Onset Is Associated With Worse Long-term Behavioral Outcomes in Anti-NMDA Receptor Encephalitis. 2021 Oct 9;22(20):10911. It is best to assume the worst and cover for this possibility.

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EM Quick Hits 35 – 10 Best Papers of 2021, Peripartum Cardiomyopathy, Crashing Asthmatic, Febrile Neutropenia, Anaphylaxis update

Emergency Medicine Cases

The post EM Quick Hits 35 – 10 Best Papers of 2021, Peripartum Cardiomyopathy, Crashing Asthmatic, Febrile Neutropenia, Anaphylaxis update appeared first on Emergency Medicine Cases.