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Direct Oral Anticoagulant (DOAC) Reversal: Part 3

The Trauma Pro

In 2021, an article was published (reference 1) that performed a systematic review of the literature from 2017 to 2020. Preventing death: This drug doesn’t appear to reduce mortality, which is the outcome we are most interested in when treating these patients. 2021 Oct 1;49(10):e1025-e1036. Thrombotic complications.

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Outcomes from out-of-hospital cardiac arrest in nursing and care homes: a cohort study

Emergency Medicine Journal

We aimed to describe the characteristics, treatments and outcome of individuals sustaining an OHCA in nursing and care home settings in England. We present descriptive statistics and compare groups, where appropriate, using a 2 test.

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emDOCs Podcast – Episode 110: Primary Spontaneous Bacterial Peritonitis

EMDocs

Older age, recurrent episodes of SBP, hepatorenal syndrome, hepatic encephalopathy, acute kidney injury (AKI), concurrent GI bleeding, and higher MELD scores are predictors of worse outcomes. 2021 Aug;74(2):1014-1048. 2021 Jan;70(1):9-29 Marciano S, Díaz JM, Dirchwolf M, Gadano A. 2021 May;19(5):976-986.e5. Hepatology.

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Sepsis Screening Decreases Mortality. Well, not really.

Sensible Medicine

The only problem was that the patient population would change over the course of the study – the unscreened population was studied mostly in 2019 and early 2020 while the screened population was mostly late 2020 early 2021. Outcomes and patients The primary outcome was 90-day in-hospital mortality. Now to the journal.

Sepsis 98
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Anti-NMDA Receptor Encephalitis in Children and Adolescents

Pediatric EM Morsels

Higher titers in both CSF and serum were associated with poor outcomes. Earlier diagnosis leads to better outcomes. Younger Age at Onset Is Associated With Worse Long-term Behavioral Outcomes in Anti-NMDA Receptor Encephalitis. 2021 Oct 9;22(20):10911. It is best to assume the worst and cover for this possibility.

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Glasgow Coma Scale in Children

Pediatric EM Morsels

Motor Fingernail bed pressure with a pencil first If flexion outcome, then apply painful stimulus to neck or head (trapezius or supraorbital notch) to look for localization Spinal reflex can result in a falsely elevated score if lower extremity pain induced Verbal Orientated- Able to answer all questions. A practical scale. PMID: 4136544.

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Chest pain and computer ‘normal’ ECG. Wait for troponin? And what is the reference standard for ECG diagnosis? Cardiologist or outcome?

Dr. Smith's ECG Blog

They concluded, "Our findings increase confidence in the normal automated GE Marquette 12 SL ECG software interpretation to predict a benign outcome. Smith comment: this is a very stupid outcome measure) What if we use that methodology for the ECG above? What is the gold standard for ECG interpretation: patient outcome!!!

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