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EM@3AM: Leukopenia

EMDocs

Answer : Leukopenia Overview Leukopenia is defined as total WBC count < 4000/mm 3 Neutropenia is the most common subset of leukopenia and is defined on absolute neutrophil count: 1 Mild (1.01.5 10^9/L) Moderate (0.50.9 10^9/L) Severe (< 0.5 10^9/L) Generalized leukopenia (i.e. Most common causes of leukopenia Infections: 36.4%

EMS 96
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ToxCard: Crotalid Envenomation Part 2 – CroFab vs. AnaVip: What’s the Difference?

EMDocs

In April 2021, after a post-hoc analysis of the original phase 3 study suggested non-inferiority of the F(ab’) 2 antivenin against copperhead envenomation, the FDA expanded approval of this antivenom to include copperhead and cottonmouth envenomations. Published online April 2021. Ann Emerg Med. 2020;76(4):S29. Accessed May 7, 2022.

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emDOCs Podcast – Episode 94: GLP-1 Agonist Complications

EMDocs

Hypersensitivity/dermatologic: GLP-1 agonists are synthetic peptides; may lead to antibody formation and allergic reaction/injection site reaction. Reactions are usually minor: transient warmth, pruritis at injection site that resolves. Adverse drug reactions of GLP-1 agonists: A systematic review of case reports.

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EM@3AM: Traumatic Iritis

EMDocs

Dilation of conjunctival vessels resulting in hyperemia and edema (A) is the underlying pathophysiology of conjunctivitis, which can be brought on by infection or allergic reaction. 2021 Oct 7. Close follow-up within 48 hours with an ophthalmologist is appropriate for ongoing monitoring and care. and John O.

EMS 98
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What the Emergency Clinician Must Know about Remote Monitors in Heart Failure

EMDocs

10 This procedure has well-described rare complications including infection, blood loss, allergic reaction, arrhythmia, pneumothorax if approaching via the internal jugular vein, embolization of the device, and pulmonary artery perforation or dissection. 2021 Jan;14(1):e008693. 8 The device itself is 2 x 2.5 doi: 10.1161/CIRCEP.120.008693.

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The PALACE Trial: Direct Oral PCN Challenge in Patients with Low-Risk PCN Allergy?

RebelEM

What They Did: Parallel, 2-arm, noninferiority, open-label, multicenter, international randomized clinical trial Occurred in 6 specialized centers (3 in North America – US & Canada and 3 Outside of North America – Australia) Trial took place from June 2021 to December 2022 Used PEN-FAST to risk stratify patients.

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Nephrotic Syndrome

Mind The Bleep

Steroid resistance Failure to achieve complete remission after 8 weeks of prednisolone at 60mg/m2/day Differentials Heart failure – would present with oedema, shortness of breath, cyanosis Allergic reaction – presents with facial oedema, pruritus. This causes a positive feedback mechanism with the liver producing more albumin.