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Direct Oral Anticoagulant (DOAC) Reversal: Part 3

The Trauma Pro

In 2021, an article was published (reference 1) that performed a systematic review of the literature from 2017 to 2020. Preventing death: This drug doesn’t appear to reduce mortality, which is the outcome we are most interested in when treating these patients. Thrombotic complications.

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Sepsis Screening Decreases Mortality. Well, not really.

Sensible Medicine

The only problem was that the patient population would change over the course of the study – the unscreened population was studied mostly in 2019 and early 2020 while the screened population was mostly late 2020 early 2021. Outcomes and patients The primary outcome was 90-day in-hospital mortality.

Sepsis 98
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Long-Term Outcomes in Patients Using Protocol-Directed Active Surveillance for Prostate Cancer

Sensible Medicine

In this context, the Canary Prostate Active Surveillance Study ( PASS ) sought to understand the long-term outcomes of active surveillance. Question What are the long-term outcomes for patients with favorable risk prostate cancer managed with protocol-directed active surveillance?

Outcomes 102
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Anti-NMDA Receptor Encephalitis in Children and Adolescents

Pediatric EM Morsels

Higher titers in both CSF and serum were associated with poor outcomes. Earlier diagnosis leads to better outcomes. Younger Age at Onset Is Associated With Worse Long-term Behavioral Outcomes in Anti-NMDA Receptor Encephalitis. 2020 Feb;75:55-62. It is best to assume the worst and cover for this possibility. 2019.12.016.

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Ultrasound in Cardiac Arrest

Mount Sinai EM

Initially, data suggested that the use of ultrasound during arrest increased pauses between compressions which worsens outcomes. Ultrasound during cardiac arrest has quickly become standard. To decrease time between compressions, many protocols were proposed (see here ).

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Chest pain and computer ‘normal’ ECG. Wait for troponin? And what is the reference standard for ECG diagnosis? Cardiologist or outcome?

Dr. Smith's ECG Blog

They concluded, "Our findings increase confidence in the normal automated GE Marquette 12 SL ECG software interpretation to predict a benign outcome. Smith comment: this is a very stupid outcome measure) What if we use that methodology for the ECG above? What is the gold standard for ECG interpretation: patient outcome!!!

EKG/ECG 89
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Hemolytic Uremic Syndrome (HUS): Rebaked Morsel

Pediatric EM Morsels

HUS findings: Microangiopathic hemolytic anemia , Renal failure , and Thrombocytopenia The most dreaded outcomes of HUS include need for renal replacement therapy both short and long term and unfortunately death. It is critical to detect HUS early in its disease course to ensure the best outcomes. Epub 2010 Jan 13. PMID: 20075028.