Cetirizine Vs Diphenhydramine For the Treatment of Acute Urticaria in the ED
RebelEM
JANUARY 23, 2023
Background: Diphenhydramine, a first-generation antihistamine, is the most common pharmacologic agent used to treat acute allergic reactions. Ann Emerg Med 2020. While the need for parenteral therapy is apparent in anaphylaxis, it’s more nebulous in minor and moderate non-life-threatening reactions such as urticaria.
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