Cetirizine Vs Diphenhydramine For the Treatment of Acute Urticaria in the ED
RebelEM
JANUARY 23, 2023
Background: Diphenhydramine, a first-generation antihistamine, is the most common pharmacologic agent used to treat acute allergic reactions. Second-generation H1 antihistamines (cetirizine, loratadine, and fexofenadine) do not cross the blood-brain barrier as easily (Bernstein J 2018). Patterson’s allergic diseases.
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