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ACMT Toxicology Visual Pearls: On the Mark

ALiEM

They were first developed in the 1950s by the Nazis and were used in chemical warfare in the Iran-Iraq War in the 1980s, by the Japanese Aum Shinrikyo cult in Tokyo, and in Syria in the 2010’s. What are the symptoms of nerve agent poisoning? [1, Use benzodiazepines such as diazepam or midazolam for seizures. Chemical terrorism.

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ToxCard: Benzonatate

EMDocs

8) Over the next 24 years, numerous peer reviewed publications on benzonatate poisoning appeared in the medical literature. (3, 3, 7) The accumulating post marketing adverse event reports led to the FDA release of a Drug Safety Communication (DSC) in 2010, over 50 years after initial approval. (9)

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ToxCard: N-Acetylcysteine for Acetaminophen Toxicity

EMDocs

These local protocols vary from the labeled dosing; contacting and using your local poison center’s protocol is recommended. Extracorporeal treatment for acetaminophen poisoning: recommendations from the EXTRIP workgroup. 2010 Aug;48(7):770]. Clin Toxicol (Phila). 2015;53(10):941-949. Clin Toxicol (Phila). Epub 2014 Aug 18.

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ToxCard: PNU (Vacor)

EMDocs

Shortly after this, he began vomiting, and developed a tonic clonic seizure. There was no prodromal illness, recent trauma, polyuria or polydipsia, family history of seizure disorder or diabetes. When should I suspect PNU poisoning? How do I treat PNU poisoning? Fortunately, PNU poisoning is rare. N Engl J Med.

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The Toxic Shelf

Cook County EM Blog

This subsequently led the FDA to issue a Black Box Warning in 2010 which warned that the capsules resemble candy and may be visually appealing to young children. Signs and symptoms of toxicity include alerted mental status, seizures, CNS depression, apnea, respiratory failure, hypotension, ventricular dysrhythmias, and cardiac arrest.

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ToxCard: Bupropion

EMDocs

Bupropion lowers the seizure threshold and even at therapeutic doses patients can have seizures. 6 Severe toxicity: Seizures: It is unclear if seizures are caused by bupropion or the active metabolite, hydroxybupropion. 3 Seizures are dose-dependent. 3 Seizures are dose-dependent.

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Episode 19 - Cannabinoids: Emerging Evidence in Use and Abuse

EB Medicine

Jeff: Medicinally, cannabinoids are currently used in the treatment of chronic pain syndromes, complications of multiple sclerosis and paraplegia, weight loss due to appetite suppression in HIV/aids, chemotherapy-induced nausea and vomiting, seizures, and many other neuropsychiatric disorders.