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ToxCard: Benzonatate

EMDocs

8) Over the next 24 years, numerous peer reviewed publications on benzonatate poisoning appeared in the medical literature. (3, 3, 7) The accumulating post marketing adverse event reports led to the FDA release of a Drug Safety Communication (DSC) in 2010, over 50 years after initial approval. (9) Pharmacoepidemiol Drug Saf.

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ToxCard: Diethylene Glycol

EMDocs

In mass poisoning cases, DEG has been substituted as a solvent in oral medications and in topical medicinal products. 4 Despite the policy changes in the United States, epidemic poisonings involving DEG continue to impact adults and children on a global scale with 14 mass poisonings occurring since the Sulfanilamide Disaster.

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ACMT Toxicology Visual Pearls: On the Mark

ALiEM

They were first developed in the 1950s by the Nazis and were used in chemical warfare in the Iran-Iraq War in the 1980s, by the Japanese Aum Shinrikyo cult in Tokyo, and in Syria in the 2010’s. What are the symptoms of nerve agent poisoning? [1, Therapy for acute nerve agent poisoning: An update. Chemical terrorism. McGraw Hill.

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ToxCard: PNU (Vacor)

EMDocs

When should I suspect PNU poisoning? How do I treat PNU poisoning? Background: N-3-pyridylmethyl-N-p-nitrophenylurea (PNU, Pyrinuron, Pyriminil) was released in 1975 as a “safe” poison to use against mice resistant to anticoagulant rodenticides.¹ Fortunately, PNU poisoning is rare. Elsevier; 2010:2153-2217.

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ToxCard: N-Acetylcysteine for Acetaminophen Toxicity

EMDocs

These local protocols vary from the labeled dosing; contacting and using your local poison center’s protocol is recommended. Extracorporeal treatment for acetaminophen poisoning: recommendations from the EXTRIP workgroup. 2010 Aug;48(7):770]. Clin Toxicol (Phila). 2015;53(10):941-949. Clin Toxicol (Phila). Epub 2014 Aug 18.

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Dantrolene for Malignant Hyperthermia

Resus Review

Dantrolene may also be useful in life-threatening cases of dinitrophenol poisoning. The report by Siegmueller was published in Emergency Medicine Journal 2010. Once a patient has been successfully treated for 48 hours with intravenous dantrolene may be stopped.

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ToxCard: Bupropion

EMDocs

6,15 Discuss cases of overdose, including pediatric exploratory ingestions, with a medical toxicologist or your local poison center. An 11-year review of bupropion insufflation exposures in adults reported to the California Poison Control System. 2010; 48(8):800-5 Robinson S. Accessed 12/18/2022. Clin Toxicol (Phila).