RebelEM

MAY 25, 2023

Lancet 2010 [10] >20,000 adult trauma patients with SBP <90mmHg Patients randomized to TXA 1g over 10 min + 1g IV over 8hrs vs Placebo given within 8hrs of injury In-hospital mortality by 28d reduced (14.5% 2010; 376(9734):23-32. Lancet (London, England). PMID: 20554319 The CRASH-3 Trial Collaborators.

Resuscitation 145

Resuscitation Fluid Resuscitation Head Injuries Shock 145

Pediatric EM Morsels

JULY 5, 2024

risk of C Spine injury) Altered Mental Status (GCS 3-8 or U on AVPU) Abnormal ABCs on exam Focal Neurologic Deficits (paresthesia, numbness, weakness) Not Negligible Risk (2.8% Factors associated with cervical spine injury in children after blunt trauma. 2010; doi:10.1016/j.annemergmed.2010.08.038. High Risk (12.8% 2010.08.038.

Pediatrics 164

Pediatrics Head Injuries Dislocations Research 164

The Skeptics' Guide to EM

MAY 30, 2020

This study published in 2010 showed an absolute mortality reduction of 1.5% Lancet 2010 ) CRASH-3 was a well-designed, large, multi-centred randomized placebo controlled trial published in October 2019 ( The Lancet ). It asked if TXA had a mortality benefit in patients with isolated head trauma ( SGEM#270 )? TXA vs. 19.8%

Head Injuries 52

Head Injuries Academics EMS Stroke 52

The Skeptics' Guide to EM

OCTOBER 17, 2020

Background: The CRASH-2 trial, published in 2010, showed a 1.5% However, patients with significant head injury were excluded in this study and it was unclear of the effect of TXA in this group. mortality benefit (NNT 67) for patients with traumatic hemorrhage who received tranexamic acid (TXA) compared to placebo.

EMS 52

EMS Head Injuries Outcomes Hospitals 52

Downeast Emergency Medicine

APRIL 26, 2021

CRASH-3 TRIAL COLLABORATORS This international, multi-center, randomized, placebo-controlled trial looked at the effects of TXA on head injury-related death, disability, and adverse events in adult patients with TBI. The primary outcome was head injury-related death in-hospital within 28 days of injury.

Head Injuries 52

Head Injuries Administration Outcomes Seizures 52

PHEM Cast

APRIL 19, 2016

Prehospital paediatric RSI We do it less despite similar injury aetiology/patterns Most children’s airways can be managed by basic manoeuvres However, children with a significant head injury deserve best airway care – ventilation, metabolic, haemodynamics, positioning.

Head Injuries 52

Head Injuries Ambulance Services Hospitals Leadership 52

Taming the SRU

FEBRUARY 12, 2024

After rescue, she had an apparent head injury and was confused but protecting her airway with grossly normal vital signs. She initially agreed to be transported to the hospital by ambulance, but jumped from the moving vehicle and was subsequently struck and pinned under the fuselage for 10-15 minutes. BMC Pharmacol Toxicol.

Administration 80

Administration Fractures Anaphylaxis Head Injuries 80