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Cerebral Edema and Diabetic Ketoacidosis: Rebaked

Pediatric EM Morsels

The exact mechanism is not known… It was previously believed that it was due to rapid changes in serum osmolality during initial fluid resuscitation. Low morbidity and mortality in children with diabetic ketoacidosis treated with isotonic fluids. 2010 Dec;1(2):103-20. The mortality rate for cerebral edema is 21%–24%.

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Trauma Resuscitation Updates

RebelEM

CRYSTALLOIDS Too much crystalloid resuscitation in traumatic hemorrhagic shock can increase dilutional coagulopathy, as well as increase morbidity and mortality Bickell WH et al. I recently gave a talk on the initial management of trauma patients with hemorrhagic shock. vs SBP target <90mmHg which resulted in a mortality of 33.4%

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ToxCard: PNU (Vacor)

EMDocs

Treat the DKA as you would with any other patient; insulin, appropriate fluid resuscitation, and electrolyte repletion. Elsevier; 2010:2153-2217. Niacin has been used but has a lower bioavailability than nicotinamide and can cause hypotension when given. Orthostatic hypotension can persist for months after ingestion.

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Managing a patient with decompensated liver cirrhosis

Mind The Bleep

9 There is no role for Tranexamic acid in upper GI bleeding and its use is harmful to patients 11 Escalate to a senior early for consideration of a higher level of care Refer for early endoscopy after resuscitation with haemodynamic stability. 2010 Feb;12(1):1-6. On Day 3 (i.e. 48 hours later) albumin is administered at 1g/kg.

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Review of the ATHOS 3 trial

Northwestern EM Blog

Severe shock is defined as persistent hypotension requiring vasopressors to maintain a mean arterial pressure of 65mmHg and serum lactate <2 despite adequate volume resuscitation. Expert Review of Cardiovascular Therapy 2010; 8(12): 1723-9 PMID: 21108554 Santacruz CA, Pereira AJ, Celis E, Vincent JL. NEJM 2008; 358(9): 877 – 87.

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Grand Rounds Recap 3.15.23

Taming the SRU

Yates Anaphylaxis Pathophysiology Type 1 Hypersensitivity Reaction IgE-mediated Mast-cell degranulation of vasoactive materials Reaction occurs in minutes Clinical Definition: Acute onset of illness with involvement of the skin, mucosal tissue or both + one of the following Respiratory compromise Reduced BP Or, acute onset of illness with at least (..)

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Episode 7: Sepsis

PHEM Cast

It is worth noting, that with “Sepsis 3” many of these terms will become out-of-date – but validation work is required… The Rivers’ paper can be accessed here: [link] It was a single centre study which compared standard care with protocolised resuscitation packaged together as early goal-directed therapy (EGDT).

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