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Cerebral Edema and Diabetic Ketoacidosis: Rebaked

Pediatric EM Morsels

The exact mechanism is not known… It was previously believed that it was due to rapid changes in serum osmolality during initial fluid resuscitation. Low morbidity and mortality in children with diabetic ketoacidosis treated with isotonic fluids. 2010 Dec;1(2):103-20. The mortality rate for cerebral edema is 21%–24%.

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EM@3AM: Leukopenia

EMDocs

Management is directed based on underlying etiology, but consider fluid resuscitation, antipyretics, and antibiotics as indicated. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america. Clin Infect Dis. PMID: 21258094.

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Trauma Resuscitation Updates

RebelEM

Lancet 2010 [10] >20,000 adult trauma patients with SBP <90mmHg Patients randomized to TXA 1g over 10 min + 1g IV over 8hrs vs Placebo given within 8hrs of injury In-hospital mortality by 28d reduced (14.5% Hypotensive resuscitation during active hemorrhage: impact on in-hospital mortality. 2010; 376(9734):23-32.

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IVC Distensibility Index vs Collapsibility Index: Using the Correct Index

RebelEM

Jul 2010; PMID: 20620859. Ultrasonographic measurement of the respiratory variation in the inferior vena cava diameter is predictive of fluid responsiveness in critically ill patients: systematic review and meta-analysis. Sep 2010; PMID: 20502865 Teboul JL, et al. J Am Soc Echocardiogr. Zhang Z, et al. Intensive care medicine.

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Episode 7: Sepsis

PHEM Cast

The control group received many similar treatments as the ‘intervention’ group (just not full protocolised EGDT) highlighting that with good sepsis care (fluid resuscitation, close monitoring, early appropriate antibiotic administration), mortality can be reduced. 2010 Apr;38(4):1045–53. 2010 Apr;14(2):145–52.

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ToxCard: PNU (Vacor)

EMDocs

Treat the DKA as you would with any other patient; insulin, appropriate fluid resuscitation, and electrolyte repletion. Elsevier; 2010:2153-2217. Niacin has been used but has a lower bioavailability than nicotinamide and can cause hypotension when given. Orthostatic hypotension can persist for months after ingestion.

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Managing a patient with decompensated liver cirrhosis

Mind The Bleep

9 There is no role for Tranexamic acid in upper GI bleeding and its use is harmful to patients 11 Escalate to a senior early for consideration of a higher level of care Refer for early endoscopy after resuscitation with haemodynamic stability. 2010 Feb;12(1):1-6. On Day 3 (i.e. 48 hours later) albumin is administered at 1g/kg.