RebelEM

MAY 25, 2023

Lancet 2010 [10] >20,000 adult trauma patients with SBP <90mmHg Patients randomized to TXA 1g over 10 min + 1g IV over 8hrs vs Placebo given within 8hrs of injury In-hospital mortality by 28d reduced (14.5% The Role of Whole Blood Transfusions in Civilian Trauma: A Review of Literature in Military and Civilian Trauma.

Resuscitation 145

Resuscitation Fluid Resuscitation Head Injuries Shock 145

RebelEM

JUNE 19, 2023

Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): A randomised, placebo-controlled trial. Lancet 2010; 376(9734): 23-32. Read More Core EM: CRASH-2: Tranexamic Acid in Major Trauma References: CRASH-2 Trial Collaborators.

Blood Transfusions 105

Blood Transfusions Outcomes Administration Hyperthermia / Hypothermia 105

RebelEM

SEPTEMBER 26, 2022

As described in the CONSORT statement, the use of p-values in table 1 is inappropriate as the study is not powered to show a difference in baseline characteristics between the treatment and control group in an RCT (Schulz 2010). CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. Ann Intern Med.

Resuscitation 52

Resuscitation Blood Transfusions Outcomes Hospitals 52

Northwestern EM Blog

JANUARY 24, 2022

Those at higher risk of hypocalcemia (vitamin D deficiency, ESRD, hyperparathyroidism, burns, multiple blood transfusions, etc.) 2010; 36: 2019-2029. Hypocalcemia can be hinted at through history or by hints such as a prolonged QTc on an ECG. may have greater severity of shock with increased mortality. 2007; 25: 309-331.

Anaphylaxis 52

Anaphylaxis Shock Sepsis Resuscitation 52

Downeast Emergency Medicine

APRIL 26, 2021

Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant hemorrhage (CRASH-2): a randomized, placebo-controlled trial. Lancet 2010; 376:23-32.[ Arch Surg 2012; 147:113-119.[ Pubmed ] CRASH-2 Study Collaborators. Pdf ] Rubiano AM, Carney N, Chestnut R et al.

Head Injuries 52

Head Injuries Administration Outcomes Seizures 52

Don't Forget the Bubbles

JULY 5, 2023

Be careful if the patient has received a recent blood transfusion since it may be misinterpreted as sickle cell trait instead of sickle cell disease. In these cases, repeat the Hb electrophoresis three months after the last blood transfusion. Would you consider this patient for blood transfusion?

Blood Transfusions 126

Blood Transfusions Stroke Dehydration Sepsis 126

Pediatric EM Morsels

MARCH 7, 2025

While transfusing blood can be beneficial to those who have lost it or continue to lose it quickly, blood may not always be immediately available. Or maybe the family does not desire blood transfusions. Enter TXA or tranexamic acid , The Clot Stabilizer! 2010Jul 03;376(9734):23-32.

Pediatrics 231

Pediatrics Blood Transfusions Anaphylaxis Military 231