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Journal Club - Tranexamic Acid in Trauma

Downeast Emergency Medicine

We know that if administered too rapidly, it can lead to hypotension and other adverse effects including seizures, headaches, backache, abdominal pain, nausea, vomiting, diarrhea, fatigue, pulmonary embolism, deep vein thrombosis, anaphylaxis, impaired color vision, and other visual disturbances.[1] Lancet 2010; 376:23-32.[

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Vasopressor Nonresponse

Northwestern EM Blog

Anaphylaxis Anaphylaxis may present as hypotension alone. Thus, it may easily be confused with a different form of shock and treated with vasopressors such as norepinephrine and vasopressin, which are not first line for anaphylaxis. 2010; 36: 2019-2029. Urticaria should prompt consideration of anaphylaxis.