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Pre-Hospital Antibiotics in Sepsis?

RebelEM

Background: Sepsis remains one of the leading causes of morbidity and mortality. It is well-established that earlier recognition and treatment can lead to better outcome for these patients . Prehospital Administration of Broad-Spectrum Antibiotics for Sepsis Patients: A Systematic Review and Meta-Analysis. Health Sci Rep 2022.

Sepsis 132
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The Latest in Critical Care, 10/30/23 (Issue #18)

PulmCCM

Professional Medical Societies Call for Elimination of SEP-1 The Infectious Diseases Society of America (IDSA), along with societies for emergency medicine physicians and hospitalists, are again speaking up about the ongoing policy experiment known as the Centers for Medicare and Medicaid Severe Sepsis/Septic Shock Management Bundle (SEP-1).

Sepsis 52
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Steroids in preschool wheeze

Don't Forget the Bubbles

Randomised controlled trials addressing the benefit of steroids in preschool wheeze have compared different cohorts, used different trial designs and measured different outcomes. This is a way to overcome different trial outcomes. This paper’s primary outcome was a change in wheeze severity score (WSS). What does this mean?

Outcomes 105
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The CLOVERS Trial

Taming the SRU

Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension. doi:10.1056/NEJMoa2212663 BACKGROUND Sepsis, including severe sepsis and septic shock, is a frequently encountered condition in the emergency department and carries a high mortality rate. N Engl J Med. 2023;388(6):499-510. 2018, Kuttab, Lykins et al.

Sepsis 52
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SGEM#356: Drugs are Gonna Knock You Out – Etomidate vs. Ketamine for Emergency Endotracheal Intubation

The Skeptics' Guide to EM

A 2009 randomized control trial conducted in French ICUs supported the use of ketamine in this patient population [5]. Historically there has been concern about adrenal insufficiency caused by etomidate being harmful for patients with sepsis but this has not been shown to cause increased mortality in the literature [6, 7].

Sepsis 43
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Bubble Wrap PLUS – November ’26

Don't Forget the Bubbles

Update to the Neonatal Early-Onset Sepsis Calculator Utilizing a Contemporary Cohort. Rotavirus Vaccine Effectiveness Against Severe Acute Gastroenteritis: 2009-2022. Trends in C-Reactive Protein Use in Early-onset Sepsis Evaluations and Associated Antibiotic Use. Edwards EM, et al. Pediatrics. 2024 Oct 1;154(4):e2024065963.

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Necrotising Enterocolitis

Don't Forget the Bubbles

Despite advancements in neonatal care, NEC remains a significant concern due to its association with adverse outcomes, including prolonged hospitalisation, the need for surgical intervention, and increased mortality rates. Differential diagnoses include septic ileus, and infection causes such as sepsis, meningitis and pneumonia.