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Cerebral Edema and Diabetic Ketoacidosis: Rebaked

Pediatric EM Morsels

The exact mechanism is not known… It was previously believed that it was due to rapid changes in serum osmolality during initial fluid resuscitation. 2009 Apr;10(2):155-7. Factors associated with adverse outcomes in children with diabetic ketoacidosis-related cerebral edema. Lesson = treat early! Diabetes Ther.

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Necrotising Enterocolitis

Don't Forget the Bubbles

Despite advancements in neonatal care, NEC remains a significant concern due to its association with adverse outcomes, including prolonged hospitalisation, the need for surgical intervention, and increased mortality rates. What is the pathophysiology of necrotising enterocolitis? How do you treat necrotising enterocolitis? Can we prevent NEC?

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Haemolytic Uraemic Syndrome

Don't Forget the Bubbles

She receives fluid resuscitation, and you organise some tests to find out why she is so tired. coliO157 and factors influencing the development of typical haemolytic uraemic syndrome: a retrospective cohort study, 2009–2012. Early Volume Expansion and Outcomes of Hemolytic Uremic Syndrome. 2016 Jan;6(1):e009933.

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The CLOVERS Trial

Taming the SRU

The CLASSIC trial is a randomized controlled trial conducted in the ICU setting which compared restrictive versus standard fluid strategies with a primary outcome of death by 90 days in patients with septic shock. Safety outcomes Serious adverse event occurrences were similar in both groups. versus 59.2%). versus 14.9%

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EM@3AM: Hyperthermia

EMDocs

Clinical characteristics and outcome of thyroid storm: a case series and review of neuropsychiatric derangements in thyrotoxicosis. Outcome and risk factors associated with extent of central nervous system injury due to exertional heat stroke. Temps greater than 41.5C BMC research notes , 8 , 758. link] Swee, duS., L., & Lim, A.

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Sepsis Updates Relevant to the Emergency Physician

EMDocs

8 Based on multiple randomized controlled trials (RCTs), SSC 2021 guidelines suggest against using procalcitonin as a screening method to guide initiation of antibiotic therapy, as no difference in clinical outcomes was appreciated. 15 Two changes were elucidated in the 2021 SSC guidelines for fluid resuscitation.

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EM@3AM: Takotsubo Cardiomyopathy

EMDocs

This patient’s recent diarrheal illness raises suspicion for hypovolemia, which would be treated with fluid resuscitation (D) , but her moist oral mucosa and dilated inferior vena cava suggest an eu- or hypervolemic state. Additional fluids will not improve her condition and may worsen it. J Neurosurg. 2006;105(2):264-270.

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