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Background: Diphenhydramine, a first-generation antihistamine, is the most common pharmacologic agent used to treat acute allergicreactions. Diphenhydramine versus nonsedating antihistamines for acute allergicreactions: a literature review. 2007 Jul-Aug;28(4):418-26. Resources: Banerji A, Long AA, Camargo CA Jr.
It’s not an allergicreaction: even with the old preparations of hyaluronidase, allergicreactions were rare, and now they are very rare with the recombinant preparation. in 2007 compared subcutaneous administration of lactated ringer’s solution by gravity with and without hyalurondase. J Am Geriatr Soc.
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