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The Latest in Critical Care, 1/22/24 (Issue #26)

PulmCCM

Background Therapeutic hypothermia, later rebranded as targeted temperature management, became a standard post-cardiac arrest therapy for comatose patients after two 2002 NEJM trials ( n=273 and n=77 ) suggested reducing core temperature to 32°C to 34°C markedly improved neurologic outcomes and survival. Read on for details.

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Symptomatic Bradycardia: Considering the Differential Diagnosis

Northwestern EM Blog

Myocardial Infarction Medication Sinus node dysfunction Infectious Disease Hypothermia Metabolic Abnormalities (hypothyroidism, hyperkalemia, ect.) Hypothermia Moderate to severe hypothermia can cause significant bradycardia leading to hypotension. Hypothermia. Treatment includes permanent pacemaker placement [9].

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Targeted temperature management for post-cardiac arrest is officially over (for now)

PulmCCM

Background Therapeutic hypothermia, later rebranded as targeted temperature management, became a standard post-cardiac arrest therapy for comatose patients after two 2002 NEJM trials ( n=273 and n=77 ) suggested reducing core temperature to 32°C to 34°C markedly improved neurologic outcomes and survival. Read on for details.

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The Science on Targeted Temperature Management

ACEP Now

Early work on TTM in 2002 showed benefit to cooling to 33 degrees Celsius, which subsequently influenced international resuscitation guidelines to recommend mild hypothermia at 32 degrees to 34 degrees Celsius in 2005. Adding nuance, this study also showed that the highest-severity arrests did not benefit from hypothermia.

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Bullous Skin Lesions, Meet Emergency Medicine

Taming the SRU

Mortality rates related to bullous skin lesions are typically related to disruption of the skin barrier and include subsequent dehydration, electrolyte imbalances, hypothermia, increased metabolic needs, and secondary infection leading to bacteremia and/or sepsis. Proc Natl Acad Sci U S A 2005; 102:4134. N Engl J Med 1995; 333:1600.

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Seeing Peter Safar, and his work

Advanced Emergency Nursing from AENJ

Research into post-arrest after-care, therapeutic hypothermia, reanimatology. March-April, 2005. Helped establish the Freedom House ambulance with paramedic level care. Expanding focus of resuscitation to include the brain: CPCR; CardioPulmonary Cerebral Resuscitation. Ebemeyer, Uwe, and others. Peter Safar (1924-2003).

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EM@3AM: Hyperthermia

EMDocs

Broad-spectrum antibiotics (A) for septic shock are not inappropriate given the hyperthermia, tachycardia, and hypotension. Hyperthermia. As you attempt to examine the patient, he has a generalized, tonic-clonic seizure. What is your diagnosis, and what are your next steps in evaluation and management? 1 Fever is usually < 40C.