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An Herbal Hope: Is XBJ A Game-Changer in Sepsis Management?

RebelEM

Background: Could Xuebijing (XBJ) catalyze a paradigm shift in sepsis management? XBJ is an herbal compound used in China to manage various inflammatory and infectious processes in recent years, including sepsis. This post evaluates the recent “Efficacy of Xuebijing Injection in Patients With Sepsis (EXIT-SEP)” trial.

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Adjunctive Methylene Blue in Septic Shock?

RebelEM

Background: Sepsis can induce numerous physiologic derangements. The Influence of Methylene Blue infusion on Cytokine Levels During Severe Sepsis. Crit Care 2004. At the most severe end, this includes endothelial dysfunction leading to increased vascular permeability, abnormal nitric oxide metabolism, and vasodilation (i.e.

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REBEL Cast Ep123: Reduced-Dose Systemic Peripheral Alteplase in Massive PE?

RebelEM

PMID: 21422387 Wan S et al. Thrombolysis Compared with Heparin for the Initial Treatment of Pulmonary Embolism: A Meta-Analysis of the Randomized Controlled Trials. PMID: 15262836 Sharifi M et al. Pulseless Electrical Activity in Pulmonary Embolism Treated with Thrombolysis (from the “PEAPETT” Study). PMID: 27422214 Wang C et al.

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Bullous Skin Lesions, Meet Emergency Medicine

Taming the SRU

Mortality rates related to bullous skin lesions are typically related to disruption of the skin barrier and include subsequent dehydration, electrolyte imbalances, hypothermia, increased metabolic needs, and secondary infection leading to bacteremia and/or sepsis. Nature 2004; 428:486. DIC is an uncommon but potential complication.

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What are treatment options for this rhythm, when all else fails?

Dr. Smith's ECG Blog

The stay in the cardiac intensive care unit (CICU) was further complicated by sepsis, delirium, GI bleeding, and anuric renal failure with need for renal replacement therapy. Unfortunately, he required re-intubation a few days later due to respiratory distress from severe bilateral pneumonia.

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Diagnostics and Therapeutics: The Who, What, Where, When and Why of Lumbar Punctures

Taming the SRU

The UK joint specialist societies guideline on the diagnosis and management of acute meningitis and meningococcal sepsis in immunocompetent adults. C., & Solomon, T. The Journal of infection , 72 (4), 405–438. van de Beek, D., Cabellos, C., Dzupova, O., Esposito, S., Tunkel, A. Hartman, B. Kaplan, S. Kaufman, B. Scheld, W.

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The Undifferentiated Sick Infant

Pediatric Emergency Playbook

Check a glucose ad drug screen Sepsis - Saved for last - You'll almost always treat the sick neonate empirically for sepsis - think of congenital and acquired etiologies. Before you decide on sepsis, ask yourself, could this be a cardiac problem?* Philadelphia, PA, Lipincott Williams & Wilkins, 2004.