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Cerebral Edema and Diabetic Ketoacidosis: Rebaked

Pediatric EM Morsels

Risk Factors that seem to stay consistent: Administration of Bicarb for correction of acidosis has been shown to be associated with cerebral edema and DOES persist after correcting for severity of DKA! 2004 Jul;27(7):1541-6. PubMed] [Read by QxMD] Muir AB1, Quisling RG, Yang MC, Rosenbloom AL. Diabetes Care. PMID: 15220225.

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Adjunctive Methylene Blue in Septic Shock?

RebelEM

Judicious fluid resuscitation is indicated in patients with signs of hypo perfusion but is often inadequate necessitating the administration of vasoactive medications. Crit Care 2004. septic shock). NaCl over 6hrs once daily x3 doses Placebo: 500mL of 0.9% 95% CI 15.4 PMID: 14707556 Richards-Belle et al. Crit Care Med 2023.

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Clinical Conundrums: Should You Give the First Dose of Antibiotics IV Before Discharging Home on Oral Antibiotics?

RebelEM

Oral administration of antibiotics: a rational alternative to the parenteral route. Lancet 2004; 364: 1141-8. Read More First10EM: Magical Thinking in Modern Medicine: IV Antibiotics for Cellulitis First10EM: Oral Antibiotics are Equivalent to IV (Again) – The OVIVA Trial References MacGregor RR, Graziani AL. 1997; 24(3):457-67.

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Blood Pressure Management in Neurologic Emergencies: What Does the Evidence Say?

EMDocs

hypertensive emergency, need for thrombolytic administration) [1]. 2004 Feb;35(2):520-6. Epub 2004 Jan 15. 2004 Jun;35(6):1364-7. Epub 2004 Apr 29. When acute treatment is indicated, cautious BP lowering is suggested (~15% in the first 24 hours) [1-6]. Castillo J, et al. doi: 10.1161/01.STR.0000109769.22917.B0.

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emDOCs Podcast – Episode 90: Hypokalemic Periodic Paralysis

EMDocs

Management: Administration of PO or IV potassium. If IV administration necessary, place on continuous cardiac monitoring and administer 20 mEq/ h with a maximum dose of 200 mEq/day. 2004 Nov 9;63(9):1647-55. On exam, flaccid paralysis with little to no involvement of the bulbar or respiratory musculature. Statland JM, Barohn RJ.

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REBEL Cast Ep123: Reduced-Dose Systemic Peripheral Alteplase in Massive PE?

RebelEM

PMID: 37188358 Clinical Question: What is the efficacy and safety of low-dose (25mg) prolonged administration (over 6hrs) of alteplase in patients with massive PE? Reduced-Dose Systemic Fibrinolysis in Massive Pulmonary Embolism: A Pilot Study. Clin Exp Emerg Med 2023. PMID: 21422387 Wan S et al. PMID: 15262836 Sharifi M et al.

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An Herbal Hope: Is XBJ A Game-Changer in Sepsis Management?

RebelEM

4 XBJ received approval from the China Food and Drug Administration in 2004, 2 although the FDA of the United States has not approved it. Administration of antibiotics before randomization introduces uncertainty regarding its impact on the collected data. Evid Based Complement Alternat Med. 2021 Apr 26;2021:6621368. J Clin Med.

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