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Probiotics don’t improve outcomes in children with acute gastroenteritis

PEMBlog

The trial found that LGG did not significantly improve outcomes compared to placebo. We found that probiotics did not improve patient outcomes when compared to placebo. 2018 Nov 22;379(21):2002-2014. Why is this important for patients and caregivers ? N Engl J Med. doi: 10.1056/NEJMoa1802598. PMID: 30462938; PMCID: PMC6358014.

Outcomes 105
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Guidelines for Prehospital Management of Traumatic Brain Injury 3rd Edition: Executive Summary – PMC

PHARM

Prehospital care markedly influences outcome from traumatic brain injury, yet it remains highly variable. The Brain Trauma Foundation’s guidelines informing prehospital care, first published in 2002, have sought to identify and disseminate best … — Read on pmc.ncbi.nlm.nih.gov/articles/PMC10627685/

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Use Of Radio-opaque Markers In Penetrating Trauma

The Trauma Pro

OLYMPUS DIGITAL CAMERA The author first reviewed the literature on the use of markers for penetrating injury, which started only recently, in 2002. The reality is that no one will ever be able to design a study that definitively evaluates the very soft outcomes that result from using this technique. So yes, this is dogma.

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Adjunctive Methylene Blue in Septic Shock?

RebelEM

Without larger studies and a patient centered outcome, the addition of methylene blue within 24 hours of septic shock should still not be part of a general approach but rather an adjunct in specific circumstances (i.e. NaCl over 6hrs once daily x3 doses Placebo: 500mL of 0.9% 95% CI 15.4 NaCl over 6hrs once daily x3 doses Placebo: 500mL of 0.9%

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Universal Depression Screening Leads to Unnecessary Harm

Sensible Medicine

USPSTF Guidelines Depression screening was first recommended to adults in 2002 with a “B” grade. A 2008 Cochrane review found adult depression screening does not improve outcomes. Screening had no impact on depression, anxiety, or a host of other mental health outcomes.

Outcomes 139
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SGEM#391: Is it Time for a Cool Change (Hypothermia After In-Hospital Cardiac Arrest)?

The Skeptics' Guide to EM

Background: “Therapeutic” hypothermia took the critical care world by storm in 2002, with the simultaneous publication of two randomized control trials (RCTs) in the same issue of the New England Journal of Medicine – the Hypothermia after Cardiac Arrest ( HACA ) study and the Bernard study. Are we supposed to be starting hypothermia?”

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Cerebral Edema and Diabetic Ketoacidosis: Rebaked

Pediatric EM Morsels

Factors associated with adverse outcomes in children with diabetic ketoacidosis-related cerebral edema. 2002 Dec;141(6):793-7. Is your patient hyperglycemic, acidotic, with ketonuria? Then we’ve likely got DKA. Triple bag, triple bag, triple bag! The Pediatric Emergency Medicine Collaborative Research Commitee. PMID: 12461495.