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Adjunctive Methylene Blue in Septic Shock?

RebelEM

septic shock). Limited, small studies on its use in septic shock do not make a clear argument for use. Early Adjunctive Methylene Blue in Patients with Septic Shock: A Randomized Controlled Trial. Background: Sepsis can induce numerous physiologic derangements. Paper: Ibarra-Estrada, M et al. Crit Care 2023. 95% CI 15.4

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Glasgow Coma Scale in Children

Pediatric EM Morsels

2001 Apr;68(4):311-4. Pediatric adjusted reverse shock index multiplied by Glasgow Coma Scale as a prospective predictor for mortality in pediatric trauma. Systematic review showed 85% of studies with substantial reliability with kappa statistic >0.6 Fun fact for animal lovers!- Pediatr Neurol. 2006 May;34(5):379-87. 2005.10.012.

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Clinical Conundrums: Should You Give the First Dose of Antibiotics IV Before Discharging Home on Oral Antibiotics?

RebelEM

Except for patients with poor gut absorption or those with critical infectious processes such as septic shock or necrotizing fasciitis, this belief appears to be unfounded. 2001; 111(5):367-74. This feels intuitive as the IV route seems like it would be stronger, faster, and fix the patient better than the oral route.

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SGEM#294: Blood Pressure – Do Better, Keep Rising with NorEpi

The Skeptics' Guide to EM

Early Use of Norepinephrine in Septic Shock Resuscitation (CENSER): A Randomized Trial. Early Use of Norepinephrine in Septic Shock Resuscitation (CENSER): A Randomized Trial. One of the goals of the early treatment of septic shock is to restore end-organ perfusion. Date: June 2nd, 2020 Reference: Permpikul et al.

Sepsis 52
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Episode 21- Updates and Controversies in the Early Management of Sepsis and Septic Shock

EB Medicine

This month, we’ll be talking Updates and Controversies in the Early Management of Sepsis and Septic Shock. Optimal management of septic patients has been a source of intense research, stemming from the landmark study by Rivers in 2001. Then in 2001, sepsis-2 was introduced. Jeremy : Rivers was a real pioneer.

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The Latest in Critical Care, 10/9/23 (Issue #16)

PulmCCM

After two studies published in NEJM 2001 and 2006 showed intensive glucose control (to 80-110 g/dL) improved outcomes in adult medical and surgical patients, and then in kids (all at a single center in Leuven, Belgium), tight glucose control quickly became standard care in the U.S. and many other countries.

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An Herbal Hope: Is XBJ A Game-Changer in Sepsis Management?

RebelEM

This varies from the 2001 definition, which used SIRS criteria and was thought to overly focus on inflammation. in both groups Mean APACHE II score was 12 in both groups Almost half of the patients had septic shock at enrollment Mean time from sepsis identification to randomization was 1.4 906 randomized to the Placebo cohort.

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