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Clinical Conundrum: Should We Always Treat Fever in Patients with Sepsis?

RebelEM

A large observational study of > 2000 patients found an association with fever at presentation and ICU survival for patients with severe sepsis or septic shock ( Sunden-Culberg 2017 ). Importantly, all of the patients in this study had septic shock requiring vasopressors and mechanical ventilation.

Sepsis 71
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REBEL Cast Ep116: The CLOVERS Trial – Restrictive vs Liberal Fluids in Sepsis-Induced Hypotension

RebelEM

Background: IV fluids are part of the standard resuscitation bundle in septic shock, however it is unclear if they provide a significant benefit. The goal of the trial was to see if early vasopressors improved shock control by 6 hours. This resulted in better shock control by 6hrs (76.1% Liberal: 14.9%

Sepsis 99
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But Can You Just PO?

Taming the SRU

Other contraindications include those who are unable to drink liquid (respiratory problems or impaired unconsciousness) and patients in shock, persistent vomiting, or with an ileus. In addition to the evidence supporting its efficacy, ORT can be cost effective in comparison to IV fluids (in the appropriate context).

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A Simple Study May Herald a Big Change in Evidence-Based Medicine

Sensible Medicine

In multiple centers, slightly more than 2000 patients were randomized to either early or later starting of the anticoagulant drugs. We are shocked at the response this newsletter has achieved. In other words—a composite of bad things that can occur from not treating (more clots) or treating (bleeding). in the later treatment arm.

Stroke 98
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ACMT Toxicology Visual Pearl: Who Doesn’t Like a Nice Rosé?

ALiEM

Critical illness requiring intubation and propofol sedation Cyanide toxicity requiring sodium thiosulfate Iron toxicity treated with deferoxamine Refractory vasoplegic shock treated with methylene blue Septic shock treated with vancomycin and cefepime Reveal the Answer 3. 2000 Jun;59(6):1233-50. PMID 10575418 Kaakkola S.

Shock 64
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Very fast regular tachycardia: 2 ECGs from the same patient. What is going on?

Dr. Smith's ECG Blog

Troponin T peaked at "only" just above 2000 ng/L. The patient was shocked — and then began a long intensive process of resuscitation. The hospital stay was complicated by aspiration pneumonia, recurring ventricular tachycardia and a mural thrombus. Echocardiography showed and anterior and apical WMA with estimated LVEF 40%.

EKG/ECG 136
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Issue #2: The Latest in Critical Care, 5/22/23

PulmCCM

Read in NEJM Fluid resuscitation and vasopressors are both usually needed in septic shock , but the ideal volume of fluid to infuse before starting vasopressors has been unclear. At least one expert questioned whether the study was adequately powered. In an NHLBI-sponsored trial enrolling 1563 patients at 60 U.S.